Adfolic Tablet Uses

Adfolic tablet as a source of L-methylfolate, is primarily used to address folate deficiency and provide the benefits associated with sufficient folate levels. Following are some common uses of Adfolic Tablet:

1. Folate Deficiency: Adfolic tablet is used to treat or prevent folate deficiency, which can occur due to inadequate dietary intake, malabsorption conditions, certain medications (such as methotrexate), or increased folate requirements during pregnancy or certain medical conditions.
2. Pregnancy: Adequate folate levels are crucial during pregnancy to support fetal development and reduce the risk of neural tube defects (NTDs) in the developing baby. Adfolic tablet is often used as a supplemental source of folate during pregnancy to ensure sufficient intake.
3. Mental Health: Some studies suggest that low folate levels may be associated with an increased risk of certain mental health conditions, including depression and schizophrenia. Adfolic tablets may be used as a supplement in the management of these conditions, particularly in individuals with confirmed folate deficiency.
4. Cardiovascular Health: Folate is involved in homocysteine metabolism, and elevated homocysteine levels are associated with an increased risk of cardiovascular disease. Adfolic tablets may be recommended to help maintain normal homocysteine levels and support cardiovascular health.
5. Antimetabolite Therapy: Antimetabolites are medications commonly used to treat various conditions, including cancer, autoimmune disorders, and psoriasis. Antimetabolite can interfere with folate metabolism, leading to folate deficiency. Using Adfolic tablets can help mitigate folate depletion and reduce the associated side effects of antimetabolite treatment.

Off-label Uses of Adfolic Tablet

1. Cognitive Function and Neurological Disorders: Adfolic tablet is used to improve cognitive function and symptoms associated with certain neurological disorders, such as dementia and Alzheimer’s disease.
2. Migraine Prevention: Adfolic tablet has been used off-label as a potential preventive treatment for migraines, particularly in individuals with a specific genetic variation known as the MTHFR gene mutation. The MTHFR gene mutation affects folate metabolism, and Adfolic tablets may help address the associated deficiency and reduce migraine frequency and severity.
3. Polycystic Ovary Syndrome (PCOS): Adfolic tablets may have a positive impact on certain aspects of PCOS, such as insulin resistance and metabolic dysfunction.

Adfolic is one of the leading brands of Quatrefolic (5-MTHF, glucosamine salt), manufactured and marketed by Pharmevo Pakistan (Pvt) Ltd.

Following are some alternative brands of Adfolic and their manufacturers.

• Locyst : RG Pharmaceutica (Pvt) Ltd, Pakistan.
• Myfol : RG Pharmaceutica (Pvt) Ltd, Pakistan.
• Maxfol : High Q Pharmaceuticals (Pvt) Ltd, Pakistan.
• Folifort : Indus Pharmaceuticals, Pakistan.
• Mom Folic : Atco Laboratories Ltd, Pakistan.
• Novafol : AGP Pharma (Pvt) Ltd, Pakistan.
• Q Folic : Highnoon Laboratories, Pakistan.
• Neevo : Hiranis Pharmaceuticals, Pakistan.
• Keplin : Genetics Pharmaceuticals, Pakistan.
• Biofol : Biolex Phrama.
• Mytol F Sachet : Nexcon Pharma.

Presently, Adfolic is available in Tablet Form with the following strengths.

Adfolic Tablet : (5-MTHF, glucosamine salt) Quatrefolic 600mcg strength.

Adfolic OD Tablet : (5-MTHF, glucosamine salt) Quatrefolic 1200mcg strength.

Adfolic tablets generally have a good safety profile. However, there are a few contraindications, which are situations or conditions where the use of Adfolic is not recommended due to potential risks.

Allergy or Hypersensitivity: Adfolic should not be used in individuals who have a known allergy or hypersensitivity to L-methylfolate or any of its components.

Vitamin B12 Deficiency: Adfolic should not be used as a sole treatment for vitamin B12 deficiency. Vitamin B12 deficiency requires proper diagnosis and treatment with vitamin B12 supplements. Using Adfolic alone may mask the symptoms of vitamin B12 deficiency without addressing the underlying cause.

Leber’s hereditary optic neuropathy (LHON): LHON is a rare genetic disorder that affects the optic nerves and can lead to vision loss. Adfolic tablet is contraindicated in individuals with LHON due to the potential exacerbation of optic nerve damage.

Concurrent use with certain medications: Adfolic should be used with caution or avoided when taking certain medications that interact with folate metabolism. This includes certain antiepileptic drugs (such as phenytoin and primidone) and methotrexate, among others. Consultation with a healthcare professional is essential to assess potential interactions and determine the most appropriate course of action.

Adfolic Dose to Address Folate Deficiency:

• One Tablet of 600 mcg per day.
• In some cases, higher doses may be recommended, such as 1 to 2 tablets of Addfolic OD (1200 mcg) per day, depending on individual needs and specific health conditions.

Adfolic Dose for Depression or Other Mental Health Concerns:

• Higher doses are recommended under the guidance of a healthcare professional.
• Typically Dose ranges from 7.5 to 15 mg per day.

Adfolic serves as a methyl donor in various methylation reactions in the body. Methylation is a process by which a methyl group (CH3) is transferred to molecules, such as DNA, RNA, proteins, and neurotransmitters. These methylation reactions are vital for normal cellular function, gene expression, neurotransmitter synthesis, and detoxification processes.