Brolite Tablet Uses

Brolite tablet is used to treat generalized anxiety disorder (GAD) and sleep disorders. It belongs to the benzodiazepine class, which means it has sedative, anxiolytic (anti-anxiety), hypnotic (sleep-inducing), anticonvulsant (anti-seizure), and muscle relaxant properties. Following are some approved and off-label uses of Brolite tablets:

Approved Uses of Brolite Tablets

1. Anxiety Disorders: Brolite tablet is commonly used to treat anxiety disorders, including generalized anxiety disorder (GAD), panic disorder, and social anxiety disorder. It helps to reduce excessive anxiety, restlessness, and tension.
2. Insomnia: Due to its sedative and hypnotic effects, Brolite tablets can be used for difficulty falling asleep or maintaining sleep.
3. Muscle Spasms: Brolite tablet’s muscle relaxant properties make it useful in the treatment of muscle spasms and stiffness caused by conditions such as muscle strains, sprains, or spasticity.
4. Alcohol Withdrawal: Brolite tablets can be employed during alcohol withdrawal to manage symptoms such as anxiety, agitation, tremors, and seizures.
5. Epilepsy: Brolite tablets may be used as an adjunctive treatment in the management of epilepsy and to control certain types of seizures.

Off-label Uses of Brolite Tablet

1. Premenstrual Syndrome (PMS): Brolite tablet has been used to alleviate the emotional symptoms associated with PMS, such as mood swings, irritability, and anxiety.
2. Agitation and Aggression in Dementia: In some cases, Brolite may be used off-label to manage agitation and aggression in individuals with dementia.
3. Essential Tremor: Brolite tablet’s muscle relaxant properties have led to its off-label use in managing essential tremors, a neurological disorder characterized by the involuntary shaking of certain body parts, typically the hands.
4. Nausea and Vomiting: Brolite tablets may be used off-label to alleviate nausea and vomiting, particularly when caused by anxiety or as a side effect of other medications.

Brolite is one of the leading brands of Bromazepam, manufactured and marketed by Standpharm Pakistan (Pvt) Ltd.

Here are some alternative brands of Brolite and their manufacturers.

• Lexotanil : Roche Pakistan, Ltd.
• Relaxin : Macter Internation (Pvt) Ltd, Pakistan.
• Sambro : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Bromalex : Indus Pharma (Pvt) Ltd, Pakistan.
• Anxit : Atco Laboratories Ltd, Pakistan.
• Anzonil : Global Pharmaceuticals, Pakistan.
• Brexxel : High-Q International.
• Durazanil : Tabros Pharma.
• E-ZE : Genix Pharma (Pvt) Ltd.
• Freedom : Libra Pharmaceuticals (Pvt) Ltd.

Presently, Brolite is available in Tablet Form with the following strength.

Brolite Tablet : 3mg strength.

Brolite has some contraindications, which are specific situations or conditions in which the use of Brolite is not recommended due to the potential risks involved.

1. Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Brolite or any other benzodiazepines should not take the medication.
2. Severe Respiratory Insufficiency: Brolite can suppress respiratory function, so it is contraindicated in individuals with severe respiratory insufficiency, such as severe chronic obstructive pulmonary disease (COPD), severe asthma, or respiratory failure.
3. Sleep Apnea: Brolite should be avoided in individuals with sleep apnea, a condition characterized by pauses in breathing during sleep, as it may further suppress respiratory function.
4. Myasthenia Gravis: Myasthenia gravis, a neuromuscular disorder characterized by muscle weakness and fatigue, is a contraindication for Brolite due to its potential to exacerbate muscle weakness.
5. Acute Intoxication: Brolite should not be used in individuals who are acutely intoxicated with alcohol, sedatives, or other central nervous system depressants, as the combined effects can cause severe respiratory depression, sedation, and even coma.
6. Pregnancy and Breastfeeding: Brolite is generally not recommended during pregnancy and breastfeeding, as it may pose risks to the developing fetus or the nursing infant. It is crucial to consult with a healthcare professional for guidance in such situations.

Brolite Dose for Anxiety Disorders:

• One Tablet of 3mg per day, Once or twice daily.

Brolite Dose for Insomnia:

• 1 to 3 Tablets of 3mg taken at bedtime may be prescribed.

Brolite Dose for Alcohol Withdrawal:

• 6-18 mg per day, divided into two to three doses.
• The dosage may be adjusted based on the severity of symptoms.

Brolite Dose for Epilepsy:

• Bromazepam may be used as an adjunctive treatment for epilepsy. The dosage can vary depending on the individual’s response and the specific requirements of the condition. It is typically initiated at a low dose and adjusted gradually under medical supervision.

Brolite works by binding to specific sites on the GABA-A receptor complex, enhancing the affinity of GABA for its receptor. This potentiation of GABA’s inhibitory effects increases the frequency and duration of the chloride ion channel opening, further intensifying the inhibitory activity in the brain. As a result, Brolite produces anxiolytic, sedative, hypnotic, muscle relaxant, and anticonvulsant effects.