Gablin Capsule Uses

Gablin capsule is a medication that is primarily used to treat neuropathic pain, which is pain caused by damage or dysfunction of the nerves. It belongs to the class of drugs known as anticonvulsants or anti-epileptics. Following are some approved and off-label uses of Gablin Capsules:

Approved Uses of Gablin

1. Neuropathic Pain: Gablin is used for the treatment of neuropathic pain, which is pain that arises from damaged nerves. Using Gablin capsules can manage pain associated with conditions such as diabetic neuropathy (nerve damage due to diabetes), postherpetic neuralgia (nerve pain following shingles), and peripheral neuropathy (nerve damage caused by various underlying conditions).
2. Epilepsy: Gablin is used as an adjunctive treatment for partial-onset seizures in adults with epilepsy. It can be used in combination with other anti-seizure medications to help control and reduce the frequency of seizures.
3. Generalized Anxiety Disorder (GAD): Gablin is also used for the treatment of generalized anxiety disorder in adults. It can help alleviate excessive and persistent worry or anxiety and improve overall well-being.

Off-label Uses of Gablin Capsule

Additionally, some off-label uses of Gablin are prescribed by healthcare professionals based on clinical judgment and individual patient needs. These off-label uses may include:

1. Fibromyalgia: Gablin is sometimes used to manage the symptoms of fibromyalgia, a chronic condition characterized by widespread pain, fatigue, and other associated symptoms.
2. Social Anxiety Disorder: In some cases, Gablin may be used for the treatment of social anxiety disorder, a condition marked by excessive fear and anxiety in social situations.
3. Restless Legs Syndrome (RLS): Gablin may be used to relieve the uncomfortable sensations and urge to move associated with restless legs syndrome.

Gablin is one of the leading brands of Pregabalin, manufactured and marketed by CCL (Consolidated Chemical Laboratories (Pvt) Ltd Pakistan).

Below are some similar brands that can be used as an alternative to Gablin:

• Zeegap : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Gabica : Getz Pharmaceuticals, Pakistan.
• Lyrica : Pfizer Laboratories Ltd.
• Pegalin : Shaigan Pharmaceuticals (Pvt) Ltd, Pakistan.
• Syngab : Atco Laboratories, Pakistan.
• Pregy : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Regab : Caraway Pharmaceuticals, Pakistan.
• Xaar : Wilshire Laboratories (Pvt) Ltd, Pakistan.
• Hilin : Highnoon Laboratories, Pakistan.
• Megab : Sante (Pvt) Ltd, Pakistan.
• Breglin : Brooks Pharmaceuticals, Pakistan.

Presently, Gablin is available in Capsule Form with the following strengths.

Gablin Capsules : 75mg, 150mg, and 300mg strengths.

Gablin has certain contraindications, which are specific situations or conditions in which the use of Gablin is not recommended.

Hypersensitivity or allergy: Gablin is contraindicated in individuals who have a known hypersensitivity or allergy to Gablin or any of its components. Allergic reactions can range from mild skin rashes to more severe reactions, such as difficulty breathing or anaphylaxis.

Kidney problems: Gablin is primarily eliminated from the body through the kidneys. Therefore, it is contraindicated in individuals with severe kidney problems or those requiring dialysis. Gablin dosage adjustments are necessary for individuals with mild to moderate kidney impairment.

Heart problems: Gablin may cause certain cardiovascular effects, such as fluid retention, which can be of concern in individuals with pre-existing heart problems. It is contraindicated in individuals with congestive heart failure or other significant heart conditions.

Gablin Dose for Neuropathic Pain:

• 1 to 2 Capsules of 150mg two times a day.
• The dose may be increased based on individual response and tolerability, up to a maximum dose of One Capsule of 300mg twice a day.

Gablin Dose for Epilepsy:

• For Partial-Onset Seizures (adjunctive treatment): 1 to 2 Capsules of 150mg twice a day.
• The dose may be increased based on individual response and tolerability, up to a maximum dose of One Capsule of 300mg twice a day.

Gablin Dose for Generalized Anxiety Disorder (GAD):

• For Partial-Onset Seizures (adjunctive treatment): 1 to 2 Capsules of 150mg twice a day.
• The dose may be increased based on individual response and tolerability, up to a maximum dose of One Capsule of 300mg twice a day.

Gablin works by binding to the α2-δ subunit of voltage-gated calcium channels, which are found in the central nervous system. By binding to this subunit, Gablin reduces the influx of calcium ions into nerve cells. This inhibition of calcium channel function is thought to reduce the release of certain neurotransmitters, including glutamate, norepinephrine, and substance P, which are involved in transmitting pain signals.

Related Links:

Gablin Side Effects