Amclav Tablet Uses

Amclav tablet is primarily used for various bacterial infections when the bacteria are suspected or confirmed to be susceptible to its components. It is a broad-spectrum antibiotic medication with a combination of penicillin and β-lactam antibiotics. Following are some approved and off-label uses of Amclav Tablet:

Approved Uses of Amclav Tablet

1. Respiratory Tract Infections: Amclav tablet is often used for respiratory tract infections, including bronchitis, pneumonia, and sinusitis. It can help treat bacterial infections in the lungs, bronchi, and sinuses.
2. Urinary Tract Infections (UTIs): Amclav tablet is effective against many bacteria that cause UTIs, such as Escherichia coli. Amclav can be used to treat both uncomplicated and complicated UTIs, including pyelonephritis (kidney infection).
3. Skin and Soft Tissue Infections: Amclav tablet is used to treat skin and soft tissue infections, such as cellulitis, abscesses, and wound infections. It helps eliminate the bacteria responsible for these infections.
4. Dental Infections: Amclav tablet is commonly used for dental infections, including dental abscesses, periapical infections, and periodontal infections. It can help control the bacterial infection and reduce inflammation.
5. Intra-Abdominal Infections: Amclav tablets may be used in the treatment of intra-abdominal infections, such as peritonitis and abdominal abscesses. It can be part of a combination therapy for more severe cases.
6. Gynecological Infections: Amclav tablets can be used for gynecological infections, including pelvic inflammatory disease (PID) and postpartum infections.

Off-label Uses of Amclav Tablet

1. Prophylaxis: Amclav tablets may be used off-label as a prophylactic antibiotic to prevent infections in certain high-risk situations. This can include preventing infections before dental procedures in individuals with certain heart conditions or preventing surgical site infections in specific surgical procedures.
2. Bone and Joint Infections: Amclav tablets may be used in the treatment of bone and joint infections, such as osteomyelitis or septic arthritis. It may be used in combination with other antibiotics to target the specific bacteria causing the infection.
3. Infective Endocarditis: Amclav tablets may be used as part of antibiotic prophylaxis for individuals at high risk of infective endocarditis, an infection of the inner lining of the heart or heart valves. This is typically done before certain dental or surgical procedures in individuals with specific cardiac conditions.
4. Pediatric Infections: Amclav tablets may be used in children for the treatment of bacterial infections when other suitable antibiotic options are limited or not available. The dosage and duration of treatment should be carefully determined based on the child’s age, weight, and the severity of the infection.

Amclav is one of the leading brands of Amoxicillin and Clavulanic acid (also known as Co-amoxiclav), manufactured and marketed by Getz Pharmaceuticals (Pvt) Ltd. Pakistan.

Below are some available similar brands that can be used as an alternative to Amclave:

• Augmentin : GlaxoSmithKline (GSK).
• Amoxiclav : Novartis Pharma (Pvt) Ltd.
• Calamox : Bosch Pharmaceuticals (Pvt) Ltd.
• Co-Amoxi : Macter International (Pvt) Ltd.
• Fortecin : Searle Pakistan (Pvt) Ltd.
• Rite : Werrick Pharmaceuticals.
• Termibex : Highnoon Laboratories (Pvt) Ltd.
• Ultrex : Wilshire Laboratories (Pvt) Ltd.
• Zamovlav : Zafa Pharmaceutical Laboratories (Pvt) Ltd.
• Lavomox : Bloom Pharmaceuticals (Pvt) Ltd.

Presently, Amclav is available in Tablet, Suspension, and Drops Forms with the following Strengths.

Amclav Tablet 375mg:

• Amoxicillin 250mg + Clavulanic Acid 125mg strengths.

Amclav Tablet 625mg:

• Amoxicillin 500mg + Clavulanic Acid 125mg strengths.

Amclav Tablet 1g (1000mg):

• Amoxicillin 875mg + Clavulanic Acid 125mg strengths.

Amclav Suspension 156.25/5ml:

• Amoxicillin 125mg/5ml + Clavulanic Acid 31.25mg/5ml strengths۔

Amclav DS Suspension 312.5/5ml:

• Amoxicillin 250mg/5ml + Clavulanic Acid 62.5mg/5ml strengths۔

Amclav Plus Suspension 457/5ml:

• Amoxicillin 400mg/5ml + Clavulanic Acid 57mg/5ml strengths۔

Amclav Drops 62.5/5ml:

• Amoxicillin 50mg/5ml + Clavulanic Acid 12.5mg/5ml strengths۔

Amclav has several contraindications, which are specific situations or conditions in which the use of the medication is not recommended or should be avoided.

Some contraindications associated with Amclav:

Hypersensitivity or allergic reaction: Amclav is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Amclav, amoxicillin, clavulanic acid, or any other penicillin antibiotics. Allergic reactions to penicillin can range from mild skin rashes to severe allergic reactions, including anaphylaxis, which is a life-threatening condition.

Previous severe allergic reaction: Amclav is contraindicated in individuals who have experienced a severe allergic reaction, such as anaphylaxis, to Amclav or any other beta-lactam antibiotics (e.g., penicillins, cephalosporins).

History of liver injury: Amclav is contraindicated in individuals with a history of liver injury associated with Amclav or other amoxicillin/clavulanic acid-containing products. Amclav can potentially cause liver toxicity, and individuals with pre-existing liver disease or a history of liver injury may be at higher risk.

Infectious mononucleosis: Amclav is contraindicated in individuals with infectious mononucleosis (also known as glandular fever) due to an increased risk of skin rash. The use of Amclav in these cases may cause a generalized skin reaction.

Amclav Dose for Adults and Adolescents (12 years and older):

• One tablet of 375mg three times a day or 500 mg/125 mg twice a day.

Amclav Dose for More Severe Infections:

• One tablet of 625mg three times a day or one tablet of 1g twice a day.
• The duration of treatment can range from 5 to 14 days, depending on the infection being treated.

Amclav Dose for Children (3 months to 12 years):

• The dose of Amclav for children is determined based on their body weight.
• The typical recommended dose is 25 mg/5 mg per kg of body weight per day, divided into two or three doses.
• The maximum daily dose should not exceed 45 mg/6.4 mg per kilogram of body weight.
• The duration of treatment is usually 5 to 10 days.

Each component of Amclav has its own mode of action, and together they work synergistically to combat bacterial infections.

1. Amoxicillin: It is a penicillin antibiotic that belongs to the beta-lactam class of antibiotics. It works by inhibiting the synthesis of bacterial cell walls, specifically by interfering with the enzymes involved in the construction of the peptidoglycan layer, a vital component of the bacterial cell wall. This disruption weakens the cell wall, leading to bacterial cell lysis and death.
2. Clavulanic acid: It is a beta-lactamase inhibitor. Beta-lactamase enzymes are produced by some bacteria to inactivate beta-lactam antibiotics, including penicillins. Clavulanic acid acts as a competitive inhibitor of beta-lactamase enzymes, preventing them from breaking down amoxicillin. This allows amoxicillin to remain active against bacteria that produce beta-lactamase, extending its spectrum of activity and enhancing its effectiveness.

Related Links:

Amclav Side Effects