Mixel Capsule Uses

Mixel capsule is a medication, primarily used to treat a variety of bacterial infections. It belongs to the class of antibiotics known as cephalosporins known for its broad-spectrum activity against a wide range of bacteria. Following are some approved and off-label uses of Mixel Capsules:

Approved Uses of Mixel Capsule

1. Respiratory Tract Infections: Mixel is commonly used to treat respiratory tract infections, including acute bronchitis, community-acquired pneumonia, and sinusitis caused by susceptible bacteria.
2. Urinary Tract Infections: Mixel is effective against urinary tract infections (UTIs), including uncomplicated cystitis (bladder infection) and pyelonephritis (kidney infection).
3. Gonorrhea: Mixel has been used to treat uncomplicated gonorrhea, a sexually transmitted infection caused by the bacteria Neisseria gonorrhoeae.
4. Ear Infections: Mixel can be used for the treatment of otitis media (middle ear infection) in children and adults caused by susceptible bacteria.
5. Pharyngitis/Tonsillitis: Mixel may be used to treat bacterial throat infections, such as streptococcal pharyngitis or tonsillitis, in cases where antibiotic treatment is indicated.
6. Uncomplicated Skin and Soft Tissue Infections: Mixel can be used to treat certain uncomplicated skin and soft tissue infections caused by susceptible bacteria.

Off-label Uses of Mixel Capsule

1. Traveler’s Diarrhea: Mixel has been used off-label in the treatment of traveler’s diarrhea caused by certain bacteria, particularly in regions where the bacteria are known to be susceptible to Mixel.
2. Prophylaxis in Surgical Procedures: Mixel may be used as a prophylactic antibiotic to prevent surgical site infections in certain surgical procedures. This may be considered in specific cases where Mixel is effective against the likely pathogens involved.
3. Prostatitis: Mixel has been used in the treatment of bacterial prostatitis, an infection or inflammation of the prostate gland caused by susceptible bacteria.
4. Bacterial Gastroenteritis: In some cases, Mixel may be used in the treatment of bacterial gastroenteritis caused by certain susceptible bacteria.

Mixel is one of the leading brands of Cefixime, manufactured and marketed by High-Q International.

Below are some available alternative brands of Mixel.

• Caricef : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Cebosh : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.
• Cefiget : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Cefim : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Cefspan : Barrett Hodgson Pakistan (Pvt) Ltd.
• Fixitil : Tabros Pharma (Pvt) Ltd, Pakistan.
• Icef : ICI Pakistan Ltd.
• Linzim : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.
• Magnett : S.J. & G Fazul Ellahie (Pvt) Ltd, Pakistan.
• Maxima : Macter International (Pvt) Ltd.
• Maxpan : Indus Pharma (Pvt) Ltd, Pakistan.

Presently, Mixel is available in Capsule and Suspension Form and with the following strengths.

Mixel Capsules : 200mg and 400mg strengths.

Mixel Suspension : 100mg/5ml and 200mg/5ml strengths.

Mixel has a few contraindications, which are specific situations or conditions where the use of the medication is not recommended due to potential risks.

• Hypersensitivity: Mixel is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Mixel or any other cephalosporin antibiotics. Signs of hypersensitivity may include rash, itching, swelling, or difficulty breathing. If you have a known hypersensitivity, an alternative medication should be considered.
• Severe Renal Impairment: Mixel is primarily excreted by the kidneys, and if you have a severe renal impairment (significant kidney dysfunction), the dosage of Mixel may need to be adjusted or an alternative treatment option may be considered. It is important to discuss your kidney function with your healthcare professional before taking Mixel.
• Anaphylactic Reactions to Penicillins or Other Beta-Lactam Antibiotics: Mixel should be used with caution in individuals with a history of severe immediate hypersensitivity reactions (such as anaphylaxis) to penicillins or other beta-lactam antibiotics, as there may be an increased risk of cross-reactivity.
• Clostridium Difficile-Associated Diarrhea: Mixel is contraindicated in individuals with a history of or active Clostridium difficile-associated diarrhea. Antibiotics, including Mixel, can disrupt the normal gut flora and increase the risk of developing this bacterial infection.

Mixel Dose for Respiratory Tract Infections:

• Adults: One Capsule of 400mg once daily or divided into two equal doses of 200mg twice daily.
• Children (6 months and older): The recommended dose is weight-based and may range from 8 mg/kg/day to 12 mg/kg/day, divided into two equal doses.

Mixel Dose for Uncomplicated Urinary Tract Infections:

• Adults: One Capsule of 400mg once daily or divided into two equal doses of 200mg twice daily.

Mixel Dose for Otitis Media (Middle Ear Infection):

• Children (6 months and older): The recommended dose is weight-based and may range from 8 mg/kg/day to 12 mg/kg/day, divided into two equal doses.

Mixel is a third-generation Cephalosporin antibiotic that works by inhibiting the synthesis of bacterial cell walls. Mixel exerts its antimicrobial activity by inhibiting the activity of enzymes called penicillin-binding proteins (PBPs) that are involved in the synthesis of bacterial cell walls. By binding to PBPs, Mixel prevents the cross-linking of peptidoglycan strands, which are essential for the structural integrity of bacterial cell walls.

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Mixel Side Effects