Adverse Effects of Duride
Nausea, vomiting, diarrhea and hyperkalemia (cardiac arrythmias and tiredness), muscular weakness in the legs has been observed in patients receiving amiloride hydrochloride. Regular monitoring of electrolytes is recommended. Transient rise in serum cholesterol, triglycerides and serum urea levels, calcium depletion, nephrocalcinosis in premature infants or metabolic alkalosis may occur.
Reduced mental alertness may impair ability to drive or operate dangerous machinery. In the event of excessive diuresis, particularly in the elderly circulatory disturbances may occur. These include feeling of pressure in the head, headache, dizziness, dryness of mouth, visual impairment, dehydration, hypotension, circulatory collapse and thrombophilia. Increase in serum uric acid concentration.
Especially with severely restricted salt intake, hyponataremia may occur leading to orthostatic hypotension, calf muscle cramps, weakness, and loss of appetite, dizziness, drowsiness and vomiting.
Allergic reactions (e.g., skin rashes, interstitial nephritis, fever, vasculitis) or changes in blood picture may occur necessitating withdrawal.
Overdosage
Treatment of overdosage should be aimed at reversing dehydration and correcting electrolyte imbalance, particularly hyperkalemia. Emesis should be induced or gastric lavage performed. Treatment is symptomatic or supportive. If hyperkalemia is seen appropriate measures to reduce serum potassium must be instituted.
