Description
Xobix contains Meloxicam, an oxicam derivative, that is a member of the enolic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Composition
Xobix is available in tablet form in two strengths;
Xobix 7.5mg Tablets
Xobix 15 mg Tablets
Mechanism of action
Xobix (Meloxicam) is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of meloxicam, like other NSAIDs, is to prostaglandin syntheses (cyclooxygenase) inhibition.
Indications
Xobix (Meloxicam) is a non-steroidal anti-inflammatory drug indicated for:
- symptomatic treatment of painful osteoarthritis (arthrosis, degenerative joint disease)
- symptomatic treatment of rheumatoid arthritis
- symptomatic treament of ankylosing spondylitis
- symptomatic treatment of other painful conditions
Contraindications
Xobix is contraindicated In patients with known hypersensitivity to meloxicam. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic- like reactions to NSAIDs have been reported in such patients.
Warnings
Gastrointestinal (Gl) Effects - Risk of Gl Ulceration, Bleeding, and Perforation
Anaphylactoid Reactions
Advanced renal disease
In cases with advanced kidney disease, treatment with Xobix (Meloxicam) is not recommended. If NSAID therapy must be initiated, close monitoring of the patient's kidney function is advisable.
Pregnancy
In late pregnancy, as with other NSAIDs, Xobix (Meloxicam) should be avoided because it may cause premature, closure of the ductos arteriosus.
General Precautions
Xobix (Meloxicam) cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids.
The pharmacological activity of Xobix (Meloxicam) in reducing inflammation and possibly fever may diminish the utility of these diagnostic signs in detecting complications of presumed noninfectious, painful conditions.
