How to Take Salazopyrin
Tablets and enteric coated tablets
The dosage should be adjusted according to the patient’s response to treatment and tolerance to the drug. The tablets should be taken at regular intervals during the day, preferably in connection with meals.
Patients not previously treated with Salazopyrin are recommended to increase the dose gradually during the first few weeks. The use of enteric coated tablets will reduce the incidence of gastrointestinal side effects. The enteric coated tablets should not be crushed or broken.
Inflammatory bowel diseases Acute attacks
Adults
Severe attacks
2-4 tablets 3-4 times a day may be given in conjunction with steroids as part of an intensive management regime.
Moderate and mild attacks
2 tablets 3-4 times a day.
Children
40-60 mg/kg body weight and day, divided into 3-6 doses.
Prophylaxis against relapses
Adults
In ulcerative colitis in a state of remission a maintenance dose is recommended for keeping the patient free from symptoms, as a rule 2 tablets 2(3) times a day. Treatment with this dosage should continue indefinitely, unless adverse effects are observed. In case of deterioration, the dosage is raised to 2(-4) tablets 3-4 times a day.
Children
20-30 mg/kg body weight and day, divided into 3-6 doses.
Enteric coated tablets
Rheumatoid Arthritis
Experience has shown that the clinical effect appears within 1-2 months’ treatment, treatment with analgesics and/or non-steroidal anti-inflammatory agents-modifying effect of Salazopyrin EN-tabs is apparent. Salazopyrin EN-tabs has been shown effective and well tolerated in long term treatment.
Adults
Two enteric coated tablets twice a day, i.e. 2 grams a day. The enteric coated tablets should not be crushed or broken. When starting therapy it is advisable to increase the daily dose according to the following schedule: (Salazopyrin EN-tabs).
| Morning | Evening | |
| 1st Week | 1 Tablet | 1 Tablet |
| 2nd Week | 1 Tablet | 1 Tablet |
| 3rd Week | 1 Tablet | 2 Tablets |
| 4th Week & After | 2 Tablets | 2 Tablets |
If no response has been seen after 2 months’ treatment, the dose may be increased to 3 g per day.
Children
At present no recommendation regarding treatment with Salazopyrin EN-tabs in juvenile chronic arthritis can be given.
Suppositories
Individual. 1-2 suppositories in the morning after defaecation and in the evening. After 4-5 weeks the dosage can be reduce by half.
The local treatment can be combined with oral therapy with Salazopyrin/Salazopyrin EN-tabs.
