Liometacen (Indomethacin) Injections
Liometacen (meglumin indomethacinate) is a preparation with a marked analgesic activity. Liometacen is a water-soluble indomethacin salt.
The aqueous solution has a pH close to that of the tissues and therefore it can be injected without the danger of precipitation occurring in the tissues; the salt is hydrolyzed in circulation and releases indomethacin. Liometacen allows a rapid intervention for acute painful episodes. Liometacen must be administered only by intramuscular route (intravenous administration is strictly reserved for hospital use).
Liometacen is indicated for the symptomatic treatment of acute painful episodes during inflammatory musculoskeletal disorders.
The recommended dose is 1-2 ampoules of Liometacen a day by intramuscular route, for a sufficient period of time to achieve the therapeutic effect or as directed by the physician. In case of intravenous injection, to be used exclusively in hospital, it is advisable to dilute the contents of 1 ampoule in 250 ml of saline or glucose solution and administer intravenously through drip perfusion set; infusion speed: 25-35 drops/min. A second dose may be administered, if necessary, the same day (for a 8total of 2 doses administered separately). It is advisable not to administer other preparations in the same bottle.
- Children of less than 14 years old
- Pregnancy and breast-feeding
- Subjects with peptic ulcers or active gastro-intestinal ulcerative lesions or a history of recurrent gastro-intestinal ulcerative lesions
- Known salicylate and indomethacin hypersensitivity
- Parkinson’s disease
Furthermore, Liometacen is contraindicated during intensive diuretic treatment, in subjects with ongoing haemorrhages and haemorrhagic diathesis, as well as during treatment with anticoagulant drugs due to possible synergic action.