What is Blokium?
Blokium (Atenolol) is a synthetic, beta-selective (cardio selective) adrenoreceptor blocking agent, without membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities.
Composition
Blokium 25 mg tablets: each tablet contains 25 mg Atenolol B.P
Blokium 50 mg tablets: each tablet contains 50 mg Atenolol B.P
Blokium 100 mg tablets: each tablet contains 100 mg Atenolol B.P
Pharmacokinetics
Approximately 50% of an oral dose is absorbed from the gastrointestinal tract, the remainder being excreted unchanged in the feces. Peak blood levels are reached between 2 to 4 hours after oral administration. Blokium (Atenolol) undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by renal excretion. The elimination half-life of oral Blokium (Atenolol) is approximately 6 to 7 hours, and there is no alteration of the kinetic profile of the drug by chronic administration. Following oral doses of 50 mg or 100 mg, both beta-blocking and antihypertensive effects persist for at least 24 hours. When renal function is impaired, elimination of Blokium (Atenolol) is closely related to the glomerular filtration rate; significant accumulation occurs when the creatinine clearance falls below 35 mUmin/1.73m2.
Pharmacodynamics
Blokium (Atenolol) is a beta-adrenergic blocking agent. Blokium (Atenolol) blocks the action of the sympathetic nervous system, a portion of the involuntary nervous system. The sympathetic nervous system stimulates the pace of the heart beat. By blocking the action of these nerves, Blokium (Atenolol) reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Blokium (Atenolol) also reduces the force of heart muscle contraction and lowers blood pressure. By reducing the heart rate and the force of muscle contraction, Blokium (Atenolol) reduces heart muscle oxygen demand. Since angina occurs when oxygen demand of the heart exceeds supply, Blokium (Atenolol) is helpful in treating angina. Blokium (Atenolol), in addition to its effects on survival, has shown other clinical benefits including reduced frequency of ventricular premature beats, reduced chest pain, and reduced enzyme elevation.
