How Azomax Interacts with Other Drugs?
In patients receiving azithromycin and antacids, azithromycin should be taken at least 1 hour before or 2 hours after the antacid.
Carbamazepine
In a pharmacokinetics interaction study in healthy volunteers, no significant effect was observed on the plasma levels of carbamazepine or its active metabolite.
Cyclosporin
Some of the related macrolide antibiotics interfere with the metabolism of cyclosporin. In the absence of pharmacokinetics studies or clinical data investigating potential interaction between azithromycin and cyclosporin, caution should be exercised before co-administration of these two drugs. If co-administration is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Digoxin
No interactions have been reported in patients who have received concomitant azithromycin and cardiac glycosides. However, some of the macrolide antibiotics have been reported to impair the metabolism of diaoxin (in the aout) in some patients.
Therefore, in patients receiving concomitant azithromycin and digoxin the possibility of raised digoxin levels should be borne in mind.
Ergot derivatives
Because of the theoretical possibility of ergotism, azithromycin and ergot derivatives should not be Co-administered.
Warfarin
In a pharmacokinetics interaction study, azithromycin did not alter the anticoagulant effect of a single 15 mg dose of warfarin administered in healthy volunteers. Azithromycin and warfarin may be coadministered, but monitoring of the prothrombin time should be continued as routinely performed.
