Side Effects
Sedation and, in isolated cases, dry mouth and slight dizziness may occur at the beginning of treatment, but usually disappear spontaneously with continued medication. Weight gain has occasionally been reported.
Overdose
The main symptoms of acute overdosage include:
drowsiness to severe sedation; confusion and disorientation; tachycardia and hypotension; convulsions, especially in children; hyperexcitability in children; reversible coma. Treatment should be symptomatic. If the drug has been taken recently, the stomach should be emptied. If necessary, symptomatic treatment and monitoring of the cardiovascular system; excitation and convulsions: short-acting barbiturates, benzodiazepines.
Drug Interactions
Proasma may potentiate the effects of sedatives, hypnotics, antihistamines and alcohol.
Precautions
Anti-asthmatic drugs already in use should never be withdrawn abruptly when long-term treatment with Proasma is begun. This applies especially to systemic corticosteroids because of the possible existence of adrenocortical insufficiency in steroid-dependent patients: in such cases, recovery of a normal pituitary-adrenal response to stress may take up to one year.
During the first few days of treatment with Proasma the patient’s reactions maybe impaired. Care should therefore be exercised when driving a vehicle or operating machinery etc.
A reversible fall in the thrombocyte count in patients receiving Proasma concomitantly with oral antidiabetic agents has been observed in rare cases. Thrombocyte counts should therefore be carried out in patients taking antidiabetics concomitantly.
In diabetic patients, the carbohydrate content of the syrup (5 ml = 4 g carbohydrate) should be taken into consideration.
Although there is no evidence of any teratogenic effect, Proasma should be given to pregnant and nursing women only under compelling circumstances.
Proasma should be kept out of reach of children.
