Glimet - Metformin and Glibenclamide Contraindications

Do Not Take Glimet!

Glimet (Metformin HCI and Glibenclamide Tablets) is contraindicated in patients with:

  1. Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels >1.5 mg/dL [males], >1.4 mg/dL [females], or abnormal creatinine clearance) which may also result from ,conditions such as cardiovascular collapse shock), acute myocardial infarction, and septicemia.
  2. Congestive heart failure requiring pharmacologic treatment.
  3. Known hypersensitivity to Metforminl-lydrochioride or Glibenclamide.
  4. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.


Metformin Hydrochloride
Metformin HCI is diaiyzable with a clearance of up to 170 mL/min under good hemodynamic conditions. Therefore, hemodialysis may be useful for removal of accumulated drug from patients in whom Metformin overdosage is suspected.

Overdosage of sulfonylureas, including Glibenclamide tablets, can produce hypoglycemia. If nypogiycemtc coma is diagnosed or suspected the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood glucose at a level above 100 mg/dL.

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