Adverse Effects of Btrol
Gastrointestinal disturbances (nausea, vomiting, dirrhoea) may occur but disappear when the dosage is reduced. Giddiness and hypotension has been observed when intravenous injection is too rapid. To avoid this response the solution should not be injected more rapidly than 1 ml/min. This effect has not been observed with oral administration.
Precautions
- Dose of Btrol should be reduced in patients with renal insufficiency because of the risk of accumulation
- Patients with a previous history of thromboembolic disease may be at increased risk of venous or arterial thrombosis
- Patients with disseminated intravascular coagulation (DIC) or arterial thrombosis, who require treatment with Btrol, must be under strict supervision of a physician experienced in treating this disorder
- The drug should be used during pregnancy only if clearly needed
- Caution must be exercised when Btrol is administered to a nursing woman as the drug is present in the mother's milk at a concentration of about a hundredth of the corresponding serum levels
- The drug has had limited use in pediatric patients, principally in connection with tooth extraction. Limited data suggests that dosing instructions for adults can be used for pediatric patients needing Btrol therapy
