Zeegap 50mg 75mg 100mg 150mg capsules


Zeegap (Pregabalin) is indicated for the treatment of Neuropathic Pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, adjunctive therapy for adult patients with partial onset seizures and fibromyalgia.


Zeegap 50mg capsules contain Pregabalin….. 50mg
Zeegap 75mg capsules contain Pregabalin….. 75mg
Zeegap 100mg capsules contain Pregabalin….. 100mg
Zeegap 150mg capsules contain Pregabalin….. 150mg

Mechanism of Action

Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Still the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related pregabalin suggest that binding to the alpha2-delta subunit may be involved in pregabalin’s antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABAa, GABAb, or benzodiazepine receptors, does not augment GABAa responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

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