Entamizole DS Side Effects

Entamizole DS is a combination of (Diloxanide and Metronidazole) sometimes used to treat certain parasitic infections, particularly amoebiasis. Like any medication, Entamizole DS can have side effects, which can vary from common and mild to less common and more severe. Here are some common and less common side effects associated with Entamizole DS.

Common Side Effects:

• Gastrointestinal Disturbances: Entamizole DS may cause gastrointestinal symptoms, such as nausea, vomiting, abdominal pain, and diarrhea. These side effects are relatively common but are generally mild and temporary.
• Metallic Taste: A metallic or bitter taste in the mouth is a common side effect of Entamizole DS, and this taste alteration may also occur with the combination treatment.
• Dry Mouth: Some individuals may experience a dry or unpleasant sensation in the mouth with the use of Entamizole DS.
• Headache: Headaches can occur as a common side effect of Entamizole DS.
• Dizziness or Lightheadedness: Some people may feel dizzy or lightheaded while taking Entamizole DS.
• Dark Urine: Entamizole DS can occasionally cause the darkening of urine. This is typically harmless but should be reported to a healthcare provider if it persists.
• Mild Allergic Reactions: Skin rashes and itching are relatively common but usually not seriously associated with Entamizole DS.

Less Common Side Effects:

• Neurological Effects: Less common side effects with the use of Entamizole DS may include peripheral neuropathy, which can manifest as tingling, numbness, or weakness in the extremities. This is a more serious side effect and should be reported to a healthcare provider immediately.
• Seizures: In rare cases, Entamizole DS has been associated with seizures, especially when used at high doses or for extended periods.
• Blood Dyscrasias: Rarely, blood disorders may occur, leading to symptoms such as unexplained bruising, bleeding, or fatigue.
• Disulfiram-Like Reaction: A disulfiram-like reaction, which includes symptoms such as nausea, vomiting, and a flushed face, may occur if alcohol is consumed while taking Entamizole DS. Alcohol should be avoided during treatment with this medication.
• Liver Function Abnormalities: Elevation of liver enzymes or more severe liver problems can occur, although this is less common.
• Serious Allergic Reactions: Although rare, severe allergic reactions can develop, characterized by symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, and hives.

Entamizole DS is one of the leading brands with a combination of Diloxanide and Metronidazole, manufactured and marketed by Abbott Laboratories.

Presently, Entamizole is available in Tablet and Syrup forms

Entamizole DS Tablet : Diloxanide 500mg and Metronidazole 400mg strengths

Entamizole Tablet : Diloxanide 250mg and Metronidazole 200mg strengths

Entamizole Syrup : Diloxanide 125mg/5ml and Metronidazole 100mg/5ml strengths

1. Alcohol: Avoid consuming alcohol while taking Entamizole DS. The combination of Entamizole DS and alcohol can cause severe nausea, vomiting, abdominal cramps, headaches, and flushing. This reaction may persist for several hours after drinking alcohol and can be quite uncomfortable.
2. Warfarin: Entamizole DS can increase the effects of warfarin, a blood-thinning medication, potentially increasing the risk of bleeding. If you are taking warfarin, your healthcare provider may need to adjust your dosage and monitor your blood clotting levels (INR) more closely.
3. Lithium: Entamizole DS can increase the levels of lithium in the body, potentially leading to lithium toxicity. If you are taking lithium for a mood disorder, your healthcare provider may need to adjust your dosage and monitor your lithium levels.
4. Cimetidine: Cimetidine, which is used to reduce stomach acid, can increase the levels of metronidazole in the blood. This may increase the risk of Entamizole DS side effects. Your healthcare provider may need to adjust the dose of Entamizole DS.
5. Phenytoin: Entamozole DS may affect the metabolism of phenytoin, an anticonvulsant medication. Your healthcare provider may need to monitor your phenytoin levels and adjust the dose if necessary.
6. Barbiturates: Barbiturates like phenobarbital can increase the metabolism of metronidazole, potentially reducing its effectiveness. Your healthcare provider may need to adjust the Entamizole DS dose if you are taking barbiturates.
7. Other Antibiotics: When taking Entamizole DS with other antibiotics, especially those used to treat respiratory infections, there is a risk of additive or synergistic effects. Your healthcare provider will consider the potential benefits and risks when prescribing such combinations.
8. Certain Anticoagulants: Some anticoagulant medications may interact with Entamizole DS. This can lead to an increased risk of bleeding. If you are on anticoagulants, your healthcare provider will monitor your condition closely.