Nuberol Forte (Paracetamol + Orphenadrine Citrate) Tablets


White, oblonge scored tablets stamped Searle on one side each containing Paracetamol B.P. 650 mg and Orphenadrine Citrate B.P. 50 mg.

Mechanism of Action

In Nuberol Forte, the combined analgesic effect of Paracetamol and the muscle relaxant action of Orphenadrine Citrate provides in-depth relief from pain associated with Skeletal muscle Spasm.

Paracetamol possess analgesic and antipyretic actions similar to those of the salicylates. Analgesia is mediated peripherally and also centrally.

Orphenadrine Citrate is an orally effective muscle relaxant. Muscle relaxation is not due to a direct action on the muscle itself; rather the site of action of Orphenadrine Citrate is central. Orphenadrine is readily absorbed from the gastro-mtestinal tract and is almost completely metabolized to at least 8 metabolites.

It is mainly excreted in the urine as metabolites and unchanged drug.


For the relief of painful skeletal muscle spasm associated with chronic low back pain, sprains, strains, prolapsed intervertebral disc, muscle injury, non-articular rheumatism, tension headache, dysmenorrhea and other acute or chronic painful muscular conditions.


Nuberol Forte is contraindicated in patients hypersenitive to Paracetamol or Orphenadrine Citrate. Orphenadrine should not be given to patients of myasthenia gravis, glaucoma, urinary retention or lactating women.

Adverse Reactions

The adverse reactions reported to occur in patients using Orphenadrine Citrate include dry mouth, nausea, blurred vision, dizziness, confusion, tremor, palpitations and urinary hesitancy.

When taken in recommended doses, Paracetamol is usually free from side effects. Skin reactions, such as urticaria have rarely been noted.


1 tablet twice daily

Not recommended.

Pharmaceutical Precautions

Nuberol Forte should be protected from moisture, freezing, excessive heat and sunlight. Keep out of the reach of children.

Free Prescription Drugs Information by Dr.Thomas Williams