Interaction of Loprin with other Medicinal Products and other Forms of Interaction
Anticoagulants
Loprin (Aspirin) may potentiate the effect of heparin and increases the risk of bleeding with oral anticoagulants, antiplatelet agents and fibrinolytics. Concomitant use is not recommended.
Other non-steroidal anti-inflammatory drugs (NSAIDs)
Concurrent administration can increase side effects. Use of two or more NSAIDs increases risk of gastrointestinal haemorrhage Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly. However the limitations of these data and the uncertainties regarding extrapolation of ex vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no clinically relevant effect is considered to be likely for occasional ibuprofen use.
Corticosteroids
The risk of gastrointestinal bleeding and ulceration is increased. Corticosteroids reduce the plasma salicylate concentration and salicylate toxicity may occur following withdrawal of corticosteroids.
Carbonic anhydrase inhibitors
Reduced excretion of acetazolamide; salicylate intoxication has occurred in patients on high dose salicylate regimes and carbonic anhydrase inhibitors. Concurrent administration of carbonic anhydrase inhibitors such as acetazolamide and salicylates may result in severe acidosis and increased central nervous system toxicity.
Antacids and Adsorbents
The excretion of aspirin is increased in alkaline urine; kaolin possibly reduces absorption. Patients should be advised against ingesting antacids simultaneously to avoid premature drug release.
Mifepristone
The manufacturer of mifepristone recommends that aspirin should be avoided until eight to twelve days after mifepristone has been discontinued.
Antimetabolites
The activity of methotrexate may be markedly enhanced and its toxicity increased.
Antibacterials
The toxicity of sulfonamides may be increased.
Alcohol
Some of the effects of aspirin on the gastrointestinal tract are enhanced by alcohol.
Antiemetics
Metoclopramide enhances the effects of aspirin by increasing the rate of absorption.
ACE inhibitors
Aspirin may reduce the antihypertensive effect of ACE inhibitors.
Anti-epileptics
May enhance the effects of phenytoin and sodium valproate.
Diuretics
Antagonism of the diuretic effect of spironolactone.
Hypoglycaemic agents
Loprin (aspirin) may enhance the effects of insulin and oral hypoglycaemic agents.
Leukotriene antagonists
The plasma concentration of zafirlukst is increased.
Uricosurics
Effect of probenecid and sulfinpyrazone may be reduced.
Thyroid function tests: Aspirin may interfere with thyroid function tests.
