Spasler Neo Tablet Uses

Spasler Neo tablet is a medication primarily used to treat gastrointestinal disorders, particularly those involving abnormal muscle contractions in the intestines.

The following are some common uses and indications of Spasler Tablet:

1. Irritable Bowel Syndrome (IBS): Spasler tablet is commonly used to alleviate symptoms associated with irritable bowel syndrome, including abdominal pain, cramping, bloating, and changes in bowel habits.
2. Functional Gastrointestinal Disorders: Spasler tablets may be used for other functional gastrointestinal disorders characterized by spasms, such as functional dyspepsia and non-ulcer dyspepsia.
3. Colicky Abdominal Pain: Spasler tablet can help relieve colicky abdominal pain, which is sudden, severe, and intermittent in nature.
4. Spastic Disorders of the Gastrointestinal Tract: Spasler tablet is used for conditions characterized by spasms or abnormal contractions in the digestive tract, including the esophagus, stomach, and intestines.
5. Diverticulosis and Diverticulitis: Spasler tablets may be prescribed to help manage abdominal pain and discomfort associated with diverticular disease.
6. Inflammatory Bowel Disease (IBD): In some cases, Spasler tablets may be used as an adjunctive treatment to alleviate abdominal pain and discomfort in individuals with inflammatory bowel diseases like Crohn’s disease or ulcerative colitis.
7. Post-gastrointestinal Surgery: Spasler tablet may be used after certain gastrointestinal surgeries to help control abdominal pain and discomfort.
8. Gastrointestinal Motility Disorders: It may be used to regulate and normalize the movement of food through the digestive system in cases of motility disorders.
9. Functional Disorders of the Gallbladder and Biliary Tract: Spasler tablet may be considered in conditions characterized by spasms or dysfunction in the gallbladder or biliary tract.

Off-label Uses of Spaslet Tablet

1. Gastroesophageal Reflux Disease (GERD): Spasler tablet may be used off-label to help alleviate symptoms of GERD, such as heartburn and acid reflux, by reducing muscle spasms in the esophagus.
2. Chronic Pelvic Pain Syndrome: Spasler tablet may be considered as part of a treatment regimen for chronic pelvic pain syndrome, especially if there are symptoms of irritable bowel syndrome (IBS) alongside pelvic pain.
3. Menstrual-Related Abdominal Pain: In some cases, Spasler tablet may be used to help manage abdominal pain and discomfort associated with menstruation.
4. Postoperative Abdominal Pain: Spasler tablet may be considered to help manage abdominal pain following certain surgical procedures, particularly those involving the gastrointestinal tract.
5. Functional Abdominal Pain Syndrome: This is a condition characterized by chronic or recurrent abdominal pain without an obvious cause. Spasler tablets may be used as part of a treatment approach.
6. Painful Bladder Syndrome/Interstitial Cystitis: Spasler tablet may be considered as part of a multimodal treatment strategy for individuals experiencing pain and discomfort associated with the bladder.
7. Gastroparesis: Spasler tablet may be used off-label to help regulate gastric emptying in cases of gastroparesis, a condition where the stomach takes too long to empty its contents.

Spasler is one of the leading brands of Mebeverine, manufactured and marketed by AGP (Pvt) Ltd, Pakistan.

The following are some alternative brands of Spasler and their manufacturers.

• Colofac : Abbott Laboratories, Pakistan.
• Mevever MR : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Colospas : Nabiqasim Industries (Pvt) Ltd, Pakistan.
• Zeespa : Shaigan Pharmaceuticals (Pvt) Ltd, Pakistan.
• Aspa : Highnoon Laboratories Ltd, Pakistan.
• Colorest : Wilsons Pharmaceuticals, Pakistan.
• Sameb MR : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Baver : Glitz Pharma, Pakistan.
• Colonil : Genom Pharmaceuticals (Pvt) Ltd, Pakistan.
• Mibs : Shaheen Pharmaceuticals, Pakistan.

Presently, Spasler is available in tablet form.

Spasler Neo Tablet : 135mg strength.

Spasler Neo tablets are contraindicated (should not be used) in certain situations due to potential risks or interactions with other conditions or medications.

1. Hypersensitivity or Allergy: Individuals who have a known hypersensitivity or allergy to Mebeverine or any of its components should not use the Spasler tablet.
2. Obstructive Disorders of the Gastrointestinal Tract: Spasler tablet should not be used in cases of mechanical obstruction or other obstructive disorders of the gastrointestinal tract.
3. Severe Ulcerative Colitis: Spasler tablet is generally contraindicated in cases of severe ulcerative colitis, as it may not be effective in these situations and could potentially exacerbate the condition.
4. Severe Hepatic Impairment: Individuals with severe liver disease should avoid using Spasler tablets due to the potential for further liver damage.
5. Severe Renal Impairment: Spasler tablet should be used with caution in individuals with severe kidney dysfunction.
6. Children under 18 years of age: Spasler tablet tablets are not recommended for use in children and adolescents under 18 years of age unless specifically prescribed by a healthcare provider.
7. Pregnancy and Breastfeeding: The safety of Spasler tablets during pregnancy and breastfeeding has not been established, and therefore, it is generally not recommended in these situations.
8. Myasthenia Gravis: Spasler tablet may worsen symptoms in individuals with myasthenia gravis, a neuromuscular disorder.
9. Glaucoma: Spasler tablet should be used with caution in individuals with glaucoma, as it may increase intraocular pressure.
10. Urinary Retention: Spasler tablet may exacerbate urinary retention in individuals with conditions affecting the bladder or urinary tract.
11. Porphyria: Spasler tablet may trigger symptoms in individuals with porphyria, a group of rare genetic disorders that affect the nervous system and skin.

Spasler Neo Tablet Dose for Irritable Bowel Syndrome (IBS):

• In Adults: One tablet of 135mg, three times a day (before meals).

Spasler Neo Tablet Dose for Functional Dyspepsia or Non-Ulcer Dyspepsia:

• In Adults: One tablet of 135mg, three times a day (before meals).

Spasler Neo Tablet Dose for Pediatric Patients:

• The use of Spasler Neo tablets in children and adolescents under 18 years of age may require specific considerations and should be determined by a healthcare provider.

Spasler is a musculotropic antispasmodic drug that acts directly on the smooth muscle of the gastrointestinal tract, without affecting normal gut motility. The exact mechanism of action is not known, but multiple mechanisms have been proposed, such as:

• Antispasmodic Action:
  Spasler exerts its primary effect as an antispasmodic agent. It acts directly on the smooth muscle lining the walls of the intestines. Smooth muscles are involuntary muscles that control the movement of various organs, including the intestines.
• Blocking Calcium Channels:
  Spasler inhibits the flow of calcium ions into the smooth muscle cells. Calcium ions play a crucial role in muscle contraction. By blocking calcium channels, Spasler helps to relax and normalize the contractions of the intestines.
• Relaxation of Gastrointestinal Muscles:
  By reducing the influx of calcium ions, Spasler induces relaxation of the smooth muscle in the gastrointestinal tract. This helps to alleviate excessive and uncontrolled contractions or spasms.
• Alleviation of Abdominal Pain and Discomfort:
  The reduction in muscle spasms and normalization of intestinal contractions results in a decrease in abdominal pain, cramping, and discomfort.
• Improvement of Gastrointestinal Symptoms:
  By targeting the muscular component of gastrointestinal disorders, Spasler helps to alleviate symptoms such as bloating, flatulence, and changes in bowel habits.
• Selective Action:
  Spasler is relatively selective for the gastrointestinal tract, meaning it primarily affects the smooth muscle in this area. It does not exert significant effects on other types of muscle or organs.
• Minimal Central Nervous System Effects:
  Unlike some other antispasmodic drugs, Spasler has limited effects on the central nervous system. This means it is less likely to cause drowsiness or affect cognitive function.