Progyluton Tablet Uses

Progyluton tablet is used to prevent pregnancy and some other gynecological issues. It is a combination of female sex hormones that belong to a group of medications known as oral contraceptives. Following are some common and off-label uses of Progyluton tablets:

Common Uses of Progyluton Tablet

1. Birth Control (Contraception): Progyluton tablet is commonly used as an oral contraceptive, also known as a birth control pill. The use of Progyluton helps to prevent pregnancy by inhibiting ovulation (the release of an egg from the ovary), thickening the cervical mucus to impede sperm movement, and altering the lining of the uterus to make it less receptive to implantation.
2. Hormone Replacement Therapy (HRT): Progyluton tablet is used to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood changes. It can also help prevent bone loss (osteoporosis) and reduce the risk of certain conditions, like colon cancer.
3. Regulation of the Menstrual Cycle: Progyluton tablets can regulate and control the menstrual cycle. It is used in specific regimens to induce and regulate monthly periods, address irregular or absent periods, and treat conditions like polycystic ovary syndrome (PCOS).

Off-label Uses of Progyluton Tablet

1. Polycystic Ovary Syndrome (PCOS): PCOS is a hormonal disorder that can cause irregular periods, excess hair growth, and fertility issues. Progyluton tablets may be used to regulate menstrual cycles and address some of the symptoms associated with PCOS.
2. Endometriosis: Progyluton tablet may be used to treat endometriosis, where the tissue lining the uterus grows outside the uterus. It helps control the growth of endometrial tissue and reduces symptoms such as pain and heavy menstrual bleeding.
3. Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD): Some healthcare professionals may consider Progyluton tablets to manage symptoms of PMS and PMDD, such as mood swings, irritability, and breast tenderness. It helps regulate hormone levels and alleviate symptoms associated with these conditions.

Progyluton is one of the leading brands of Estradiol Valerate and Norgestrel, manufactured and marketed by Bayer Schering Pharma.

The following are some alternative brands of Progyluton and their manufacturers.

• Estranor : Saffron Pharmaceuticals (Pvt) Ltd, Pakistan.
• Star-Gest : Mass Pharma (Pvt) Ltd, Pakistan.
• Ovlogyn : Zafa Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.

Presently, Progyluton is available in Tablet Form with the following strength.

Progyluton Tablet : Estradiol Valerate 2mg and Norgestrel 0.5mg strengths

There are some important contraindications that should be considered before using the Progyluton tablet.

• Hypersensitivity: Individuals who have a known hypersensitivity or allergic reaction to components of the medication should not take these medications.
• Estrogen- or Progestin-Related Disorders: Progyluton should not be used in individuals with a history of estrogen- or progestin-related disorders, such as estrogen-dependent tumors (e.g., breast cancer) or a history of blood clots (e.g., deep vein thrombosis, pulmonary embolism).
• Liver Disease: Severe liver disease or impaired liver function is a contraindication for the use of Progyluton. It is metabolized in the liver, and liver dysfunction can affect their metabolism and increase the risk of adverse effects.
• Thromboembolic Disorders: Progyluton is contraindicated in individuals with a history of thromboembolic disorders, such as venous thromboembolism (including deep vein thrombosis and pulmonary embolism) or arterial thromboembolic events (such as stroke or heart attack). These medications can increase the risk of blood clot formation.
• Undiagnosed Abnormal Vaginal Bleeding: If an individual has undiagnosed abnormal vaginal bleeding, the cause of which has not been identified, the use of Progyluton is contraindicated until the cause is determined.
• Pregnancy and Breastfeeding: Progyluton should not be used during pregnancy or while breastfeeding, as it can have adverse effects on the developing fetus or nursing infant.

Progyluton Dose for Contraception:

• One tablet per day, taken orally.
• It is typically started on the first day of the menstrual cycle and taken continuously for 21 days, followed by a break of 7 days, during which withdrawal bleeding occurs.

Progyluton Dose for Hormone Replacement Therapy (HRT):

• One tablet per day, taken orally.
• The healthcare provider may adjust the dosage based on the individual’s response to treatment and may recommend a different dosage regimen.

Estradiol Valerate: The mode of action of estradiol involves binding to estrogen receptors in target tissues, such as the uterus, breast, and hypothalamus-pituitary axis. By binding to these receptors, estradiol regulates gene expression, modulates tissue growth and development, and influences the release of other hormones.

Norgestrel: The mode of action of norgestrel involves several effects, including inhibition of ovulation (the release of an egg from the ovary) by suppressing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.

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Progyluton Side Effects