Presage Injection Uses

Presage Injection also known as hCG is a hormone that plays various crucial roles in both male and female reproductive systems.

The following are some common uses and indications of Presage Injection:

1. Ovulation Induction: In women undergoing fertility treatments such as in vitro fertilization (IVF) or intrauterine insemination (IUI), Presage injection is used to trigger ovulation. It mimics the action of luteinizing hormone (LH), which is responsible for releasing mature eggs from the ovaries.
2. Supporting Corpus Luteum Function: After ovulation, the ruptured follicle transforms into a structure called the corpus luteum, which produces progesterone. Presage injection can be used to support the function of the corpus luteum when necessary, particularly in cases where there might be a deficiency in progesterone.
3. Treatment of Cryptorchidism: Cryptorchidism is a condition where the testes fail to descend properly into the scrotum. In pediatric cases, Presage injection can be used to stimulate the descent of the testes.
4. Stimulating Testosterone Production: In males with conditions affecting testicular function, Presage injection can stimulate the testes to produce testosterone. This is used in cases where there is a need to increase testosterone levels.
5. Management of Hypogonadism: In adult males with hypogonadism (insufficient testosterone production), Presage injection can be used as part of hormone replacement therapy (HRT) to support normal sexual development and function.
6. Diagnostic Tool for Pregnancy: Presage injection is the hormone detected by pregnancy tests. Its presence in the blood or urine is an indicator of pregnancy.

Off-label Uses of Presage Injection

1. Weight Loss: Presage injection has been used in some weight loss programs, particularly in combination with a very low-calorie diet. However, this use is highly controversial and not supported by robust scientific evidence. Many medical professionals do not recommend this approach for weight loss.
2. Treatment of Prepubertal Cryptorchidism: In cases of undescended testicles in prepubertal boys, Presage injection may be used to stimulate testicular descent.
3. Stimulation of Testosterone Production in Athletes: Some athletes have used Presage injection to boost testosterone levels, either during or after anabolic steroid use, to help restore natural testosterone production. This is not a recommended or safe practice and is prohibited in competitive sports.
4. Management of Persistent Müllerian Duct Syndrome: In rare cases of male pseudohermaphroditism known as Persistent Müllerian Duct Syndrome (PMDS), Presage injection may be used to promote testicular descent and function.

Presage Injection is one of the leading brands of Chorionic Gonadotropin, manufactured and marketed by Genome Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Presage Injection and their manufacturers.

• Profasi : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• IVF-C : : Galaxy Pharma (Pvt) Ltd, Pakistan.
• Ferti-C : RG Pharmaceutica (Pvt) Ltd, Pakistan.
• Genacor : Excel Pharma, Pakistan.
• Pregnyl : OBS Pharma, Pakistan.

Presently, Presage is available in Injection form.

Presage Injection : 5000IU

Presage injection has certain contraindications, which are conditions or circumstances under which its use should be avoided due to potential risks or adverse effects.

1. Hypersensitivity or Allergy: Individuals who have a known allergy or hypersensitivity to chorionic gonadotropin should not receive Presage injection.
2. Hormone-Sensitive Tumors: Presage injection can stimulate hormone-sensitive tumors such as some types of breast, ovarian, or prostate cancers. Therefore, it is contraindicated in individuals with these types of tumors.
3. Undiagnosed Vaginal Bleeding: If a patient is experiencing abnormal or undiagnosed vaginal bleeding, it is important to determine the cause before considering Presage injection.
4. Ovarian Cysts or Enlargement: If there are large ovarian cysts or the ovaries are significantly enlarged, Presage injection administration may be contraindicated due to the risk of ovarian hyperstimulation.
5. Testicular Tumors: Presage injection can stimulate hormone-sensitive testicular tumors. Therefore, it is contraindicated in individuals with these types of tumors.
6. Precocious Puberty: In cases of early onset of puberty, Presage injection should be used cautiously and only under the close supervision of a healthcare provider.
7. Active Thrombophlebitis or Thromboembolic Disorders: Presage injection may increase the risk of blood clots. It should be used with caution or avoided in individuals with a history of thromboembolic disorders.
8. Pregnancy and Breastfeeding: Presage injection is not indicated for use in pregnancy. It is a hormone detected in pregnancy tests and should not be used for inducing or supporting pregnancy.
9. Prostate Hypertrophy or Carcinoma: Presage injection can stimulate the prostate gland and may exacerbate conditions such as prostate hypertrophy or carcinoma.
10. Adrenal Gland Disorders: Presage injection may interfere with the function of the adrenal glands. It should be used with caution or avoided in individuals with adrenal disorders.
11. History of Ovarian Hyperstimulation Syndrome (OHSS): Individuals with a history of severe OHSS should be cautious when considering Presage injection administration, as it may increase the risk of recurrence.

Presage Injection Dosage for Ovulation Induction in Females:

• Single Dose: The typical dose for triggering ovulation in fertility treatments is 5000 to 10,000 IU of Presage injection.

Presage Injection Dosage for Testosterone Production in Males:

• For stimulating testosterone production in males, dosages of Presage injection can vary widely depending on the specific condition being treated. It can range from 500 to 4000 IU of hCG, administered 2 to 3 times per week.

Administration:

• Intramuscular (IM) or Subcutaneous (SC) Injection: Presage injection injections can be administered either intramuscularly or subcutaneously. The healthcare provider will determine the most appropriate method based on factors such as the patient’s condition, body habitus, and specific treatment goals.

Presage Injection provides Chorionic gonadotropin (hCG) is a glycoprotein hormone that is produced by the placenta during pregnancy. It is also produced in small amounts by the pituitary gland in men and women. hCG is similar in structure and function to luteinizing hormone (LH).

hCG works by binding to and activating the LHCG receptor, which is found on the surface of cells in the ovaries, testes, and adrenal glands. When hCG binds to the LHCG receptor, it triggers a cascade of events that leads to the production of hormones such as testosterone, progesterone, and estrogen.