Piriton Syrup Uses

Piriton syrup is an antihistamine that is used to treat a variety of allergic conditions, including hay fever, hives, and allergic skin reactions. It is also used to relieve the itching associated with chickenpox. The  following are some common uses and indications of Piriton Syrup:

1. Allergic Rhinitis: Piriton syrup can be used to alleviate symptoms of allergic rhinitis, including sneezing, runny or itchy nose, and itchy or watery eyes. Allergic rhinitis can be caused by various allergens such as pollen, dust mites, or pet dander.
2. Allergic Conjunctivitis: Piriton syrup may be prescribed to relieve symptoms of allergic conjunctivitis, which include redness, itching, and watery eyes due to an allergic reaction.
3. Urticaria (Hives): Piriton syrup is commonly used to treat urticaria, also known as hives. Urticaria is characterized by raised, itchy, and often red welts on the skin that can occur due to an allergic reaction.
4. Insect Bites or Stings: Piriton syrup can help reduce itching and swelling caused by insect bites or stings. It can provide temporary relief and help manage discomfort associated with these reactions.
5. Allergic Reactions: Piriton syrup may be used to relieve symptoms of allergic reactions, such as itching, rash, and swelling, that can occur due to exposure to allergens like certain foods, medications, or other substances.

Off-label Uses of Piriton Syrup

1. Cough and Cold: Piriton syrup may be used off-label to help alleviate symptoms associated with cough and cold, such as runny nose, sneezing, and congestion. However, antihistamines like Piriton are not usually the first-line treatment for these conditions, and other medications specifically targeting cough and cold symptoms may be more appropriate.
2. Eczema and Dermatitis: Piriton syrup may be used off-label to help relieve itching and inflammation associated with eczema and dermatitis. However, it’s important to note that antihistamines are generally not considered the primary treatment for these skin conditions, and other topical or systemic medications may be recommended by a healthcare professional.
3. Insomnia: Piriton syrup’s sedating effects may be utilized off-label to help manage insomnia or difficulty falling asleep. However, it’s important to note that prolonged or regular use of antihistamines for sleep should be discussed with a healthcare professional, as they may have potential side effects and can interfere with normal sleep patterns.

Piriton Syrup is one of the leading brands of Chlorpheniramine in oral liquid form, manufactured and marketed by GlaxoSmithKline Pharmaceuticals Ltd (GSK).

The following are some alternative brands of Piriton syrup and their manufacturers.

• Rhinol : Irza Pharma (Pvt) Ltd, Pakistan.
• Histosyn : Synchro Pharmaceuticals (Pvt) Ltd, Pakistan.
• Histagic : Lisko Pakistan (Pvt) Ltd.
• Allergex : Nabiqasim Industries (Pvt) Ltd, Pakistan.
• Allerphene : P. D. H. Pharmaceuticals (Pvt) Ltd, Pakistan.
• Amoni : Wilshire Laboratories (Pvt) Ltd.
• Chlorphenir : Orient Laboratories, Pakistan.
• Epinol-E : (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.
• Histalon : Polyfine Chempharma (Pvt) Ltd, Pakistan.
• Kasamine : Xenon Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Piriton is available in Syrup and Tablet forms.

Piriton Syrup each 5ml contains:

• Chloropheniramine: 2.5mg
• Sodium Acid Citrate: 55mg
• Ammonium Chloride: 125mg
• Glycerin: 750mg

Piriton Tablet : Chloropheniranie 4mg strength.

Piriton syrup has certain contraindications, meaning there are circumstances in which its use is not recommended or should be avoided.

1. Hypersensitivity: Piriton syrup should not be used in individuals who have a known hypersensitivity or allergic reaction to chlorphenamine maleate or any other ingredients in the syrup.
2. Newborns and Premature Infants: Piriton syrup is generally not recommended for use in newborns or premature infants, as safety and efficacy data in this age group may be limited.
3. Asthma: Piriton syrup should be used with caution in individuals with asthma. Antihistamines like chlorphenamine can cause thickening of bronchial secretions, potentially leading to respiratory difficulties in some individuals with asthma.
4. Glaucoma: Piriton syrup should be avoided in individuals with narrow-angle glaucoma, a condition characterized by increased pressure in the eye, as antihistamines can cause further elevation of intraocular pressure.
5. Prostate Hypertrophy: Piriton syrup should be used with caution in individuals with prostate hypertrophy, a condition characterized by enlargement of the prostate gland. Antihistamines can worsen urinary retention symptoms in these individuals.
6. Severe Liver Disease: Piriton syrup should be used with caution or avoided in individuals with severe liver disease, as the medication is metabolized in the liver and may require a dosage adjustment or close monitoring.
7. Pregnancy and Breastfeeding: The use of Piriton syrup during pregnancy or breastfeeding should be discussed with a healthcare professional, as there may be potential risks or the need for alternative treatment options.

Piriton Syrup Dose for Allergic Rhinitis:

• Children 1 to 2 years old: 2.5 ml (2mg) twice daily.
• Children 2 to 6 years old: 2.5 ml (2mg) to 5 ml (4mg) twice daily.
• Children 6 to 12 years old: 5 ml (4mg) to 10 ml (8mg) twice daily.
• Adults and children over 12 years old: 10 ml (8mg) to 20 ml (16mg) twice daily.

Piriton Syrup Dose for Urticaria (Hives):

• Children 1 to 2 years old: 2.5 ml (2mg) twice daily.
• Children 2 to 6 years old: 2.5 ml (2mg) to 5 ml (4mg) twice daily.
• Children 6 to 12 years old: 5 ml (4mg) to 10 ml (8mg) twice daily.
• Adults and children over 12 years old: 10 ml (8mg) to 20 ml (16mg) twice daily.

Piriton binds to histamine receptors, specifically the H1 receptors, preventing histamine from binding to these receptors. By blocking the H1 receptors, Piriton inhibits the effects of histamine in the body.

Piriton can also help reduce the release of histamine from mast cells and basophils, which are immune cells involved in allergic reactions. By limiting the release of histamine, Piriton reduces the allergic response.

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Piriton Side Effects