Orglu Tablet Uses

Orglu tablet is an antispasmodic medication used to relieve muscle spasms in the gastrointestinal tract. It is also used to relieve spasms and pain associated with gynecological and biliary tract issues.  Following are some common uses of Orglu tablets:

Common Uses of Orglu Tablet

1. Irritable Bowel Syndrome (IBS): Orglu tablet is commonly used for the symptomatic relief of irritable bowel syndrome. It helps to reduce abdominal pain and discomfort associated with IBS by relaxing smooth muscles in the gastrointestinal tract.
2. Functional Gastrointestinal Disorders: Orglu tablets may also be used for the treatment of other functional gastrointestinal disorders characterized by spasms or pain in the digestive system, such as functional dyspepsia and colonic spasms.
3. Menstrual Disorders: Orglu tablets may be used to alleviate menstrual cramps (dysmenorrhea) and reduce associated pain.
4. Gallbladder Disorders: Orglu tablet has been used in the treatment of gallbladder spasms (biliary colic) to relieve pain and discomfort.

Off-label Uses of Orglu Tablet

1. Renal Colic: Orglu tablet may be used off-label for the relief of renal colic, which is severe pain caused by the passage of a kidney stone through the urinary tract.
2. Uterine Spasms: In some cases, healthcare professionals may consider Orglu tablets for relief of uterine spasms, which are involuntary contractions of the uterine muscles.

Orglu is one of the leading brands with a combination of Phloroglucinol Trimethylphloroglucinol, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Orglu and their manufacturers.

• Spasrid : Barrett Hodgson (Pvt) Ltd, Pakistan.
• Anafortan Plus : AGP (Pvt) Ltd, Pakistan.
• Spadix : Tabros Parmaceuticals, Pakistan.
• Spasfon : Himont Pharmaceuticals (Pvt), Pakistan.
• Helispa Plus : Helix Pharmaceuticals, Pakistan.
• Gluthyl : Mass Pharma (Pvt) Ltd, Pakistan.
• Furosinol : Century Pharmaceuticals, Pakistan.
• Spastrim : Medera Pharmaceuticals, Pakistan.
• Spasmex : Angelini Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Orglu is available in Tablet Form with the following Strength.

Orglu Tablet : Phloroglucinol 80mg and Trimethylphloroglucinol 80mg strengths.

Orglu may have certain contraindications, which are situations where the use of Orglu is not recommended due to potential risks.

• Hypersensitivity or Allergy: It is contraindicated in individuals who have a known hypersensitivity or allergy to the components of the medication. Allergic reactions can range from mild skin rashes to severe reactions such as anaphylaxis.
• Severe Hepatic Impairment: Orglu should be used with caution or avoided in individuals with severe liver impairment. The medication is metabolized in the liver, and impaired liver function may affect its metabolism and clearance from the body.
• Intestinal Obstruction: It is contraindicated in individuals with mechanical intestinal obstruction, as the medication may worsen the condition.
• Porphyria: Orglu is contraindicated in individuals with porphyria, a group of rare genetic disorders that affect the production of heme, a component of hemoglobin. The medication may trigger a porphyria attack or worsen the symptoms in individuals with this condition.

Orglu Tablet Dose: The typical recommended dosage is 1 to 2 tablets taken orally, 2 to 3 times a day.

Maximum Dose of Orglu: 6 tablets in 24 hours.

Orglu has antispasmodic properties it works by relaxing the smooth muscles in the gastrointestinal tract, including the muscles of the intestines and the bile ducts. This relaxation helps to relieve spasms and reduce abdominal pain associated with gastrointestinal disorders.

How Orglu’s Ingredients Work:

• Phloroglucinol (an active ingredient of Orglu) has been shown to exhibit calcium-antagonistic activity. It inhibits the influx of calcium ions into smooth muscle cells, which contributes to the relaxation of the smooth muscles.
• Trimethylphloroglucinol (another active ingredient of Orglu) has been found to modulate the release of nitric oxide (NO) in smooth muscle cells. Nitric oxide is a signaling molecule involved in the relaxation of smooth muscles. By modulating NO release, trimethylphloroglucinol can help to promote smooth muscle relaxation.

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Orglu Side Effects