Onset Tablet Uses

Onset-8 tablet belongs to a class of drugs called serotonin 5-HT3 receptor antagonists. It is primarily used to prevent nausea and vomiting due to the following medical conditions:

1. Chemotherapy-Induced Nausea and Vomiting (CINV): Onset is frequently used to manage nausea and vomiting caused by chemotherapy treatments. It can be administered before chemotherapy to prevent these symptoms or given afterward to alleviate them.
2. Postoperative Nausea and Vomiting (PONV): Onset is effective in preventing and treating nausea and vomiting that may occur after surgery. Onset tablet is commonly used in surgical settings to help reduce these postoperative symptoms.
3. Radiation-Induced Nausea and Vomiting: Onset may be used to manage nausea and vomiting associated with radiation therapy, particularly when delivered to the abdomen or upper body.
4. Gastroenteritis: Onset can be used to treat nausea and vomiting caused by viral gastroenteritis (“stomach flu”) in both children and adults. It helps to alleviate these symptoms and prevent dehydration.
5. Hyperemesis Gravidarum: Onset may be used for pregnant women with severe morning sickness (hyperemesis gravidarum) who do not respond to other treatments. It can help reduce nausea and vomiting and improve overall well-being.

Off-label Uses of Onset 8 Tablet

1. Motion Sickness: Onset may be used off-label to alleviate symptoms of motion sickness, such as nausea and vomiting, particularly in situations where other antiemetic options have been ineffective.
2. Migraine-Associated Nausea and Vomiting: Onset may be used off-label as an adjunct treatment for the relief of nausea and vomiting associated with migraines, along with medications specifically used for migraine management.
3. Medication-Induced Nausea and Vomiting: Onset may be used off-label to manage nausea and vomiting caused by medications, such as opioid painkillers or certain psychiatric medications.
4. Chronic Nausea and Vomiting: In some cases, Onset may be used off-label to manage chronic or persistent nausea and vomiting that is not clearly associated with a specific condition.
5. Gastroesophageal Reflux Disease (GERD): Onset may be used off-label to help control nausea and vomiting associated with severe cases of GERD, although it is not typically considered a first-line treatment for this condition.

Onset is one of the leading brands of Ondansetron, manufactured and marketed by Pharmedic Laboratories Pakistan.

Here are some alternative brands of Onset and their manufacturers.

• Onden : Macter International (Pvt) Ltd.
• Adosetron : Searle Pakistan (Pvt) Ltd.
• Onderon : Wilsons Pharmaceuticals.
• Zofran : Glaxosmithkline.
• Espasevit : Rotex Medica Pakistan (Pvt) Ltd.
• Onseron : Indus Pharma (Pvt) Ltd.
• Averon : Aries Pharmaceuticals (Pvt) Ltd.
• Ondigo : Goodman Laboratories.
• Oniron : Genome Pharmaceuticals (Pvt) Ltd.
• Osetron : Wns field Pharmaceuticals.

Presently, Onset is available in Tablet and Injectable Forms

Onset Tablets : 8mg Strength

Onset Injections : 4mg and 8mg

There are some conditions that may contraindicate the use of either Onset tablet.

Hypersensitivity: Onset is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Onset or any of its components.

Severe Liver Impairment: Individuals with severe liver impairment should use Onset with caution, as the medication is primarily metabolized in the liver. Impaired liver function may affect its clearance from the body.

Concurrent Use with Apomorphine: Onset should not be used concomitantly with apomorphine, a medication used to treat Parkinson’s disease. Combining these medications can lead to a significant drop in blood pressure and loss of consciousness.

Congenital Long QT Syndrome: Onset is contraindicated in individuals with a history of congenital long QT syndrome, a heart rhythm disorder that can increase the risk of potentially life-threatening arrhythmias.

Concomitant Use with Serotonergic Drugs: Onset should not be used concurrently with other serotonergic drugs, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), due to the potential risk of serotonin syndrome.

Dosage of Onset 8mg tablet:

The typical dose of Onset is 8mg tablet taken up to 3 times per day. This dose may be adjusted according to your healthcare provider’s recommendation, depending on the severity of your symptoms.

Gosage of Onset Injection (Intravenous):

The typical dose for intravenous (IV) Onset is 4 mg given once every four hours for up to three doses per day. The dosage may be adjusted based on how well it works for you, as well as any other medications you are taking at the same time.

Onset is a selective serotonin 5-HT3 receptor antagonist. It binds to and blocks the serotonin 5-HT3 receptors located in the central nervous system (CNS) and peripheral organs, such as the gastrointestinal tract.

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Onset Side Effects