Motilium Tablet Uses

Motilium tablet is used to treat nausea, vomiting, and other gastrointestinal symptoms. It is an antiemetic and prokinetic medication that helps to relieve gastric motility-related issues. Following are some common and off-label uses of Motilium tablets:

Common Uses of Motilium Tablet

1. Nausea and Vomiting: Motilium tablet is used to treat nausea and vomiting caused by a variety of factors, including pregnancy, motion sickness, chemotherapy, and radiation therapy.
2. Gastroparesis: Gastroparesis is a condition characterized by delayed emptying of the stomach, which can lead to symptoms such as nausea, vomiting, bloating, and abdominal pain. Motilium tablet is used to improve peristalsis movements and relieve these symptoms.
3. Reflux Esophagitis: Reflux esophagitis is a condition in which stomach acid flows back into the esophagus, causing heartburn and other symptoms. Motilium tablets can help to reduce acid reflux by increasing the tone of the esophageal sphincter, which is the valve that separates the esophagus from the stomach.
4. Dyspepsia: Motilium tablets can be used to relieve symptoms of dyspepsia, such as bloating, discomfort, and nausea.

Off-label Uses of Motilium Tablet

1. Breast Milk Production: Motilium tablet is sometimes used off-label to increase breast milk production in women who are breastfeeding. It increases the levels of prolactin, a hormone that stimulates milk production.
2. Treatment of Gastroparesis in Diabetes: In some cases, Motilium tablets may be considered for treating gastroparesis in diabetic individuals.
3. Functional Dyspepsia: Motilium tablet has been used off-label for functional dyspepsia, a condition characterized by chronic or recurrent pain or discomfort centered in the upper abdomen, often accompanied by bloating, early satiety, or nausea.
4. Chronic Idiopathic Constipation: It is a condition characterized by persistent constipation that is not caused by another medical condition. Motilium tablets can help to relieve constipation by increasing intestinal motility.

Motilium is one of the leading brands of Domperidone, manufactured and marketed by Janssen Pharmaceutica.

The following are some alternative brands of Motilium and their manufacturers.

• Domel : Barrett Hodgson Pakistan (Pvt) Ltd
• Peridone : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Vomilux : Atco Laboratories, Pakistan.
• Pelton V : Global Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emiset : Platinum Pharmaceuticals (Pvt) Ltd, Pakistan.
• Domflash : Next Pharma (Pvt) Ltd, Pakistan.
• Stomacol : High Q Pharmaceuticals (Pvt) Ltd, Pakistan.
• Nomit : Le Mendoza Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emidone : Pharmix Laboratories (Pvt) Ltd.
• Millium : English Pharmaceuticals Industries.

Presently, Motilium is available in Tablet and Syrup forms.

Motilium Tablet : 10mg strength.

Motilium Syrup : 1mg/ml strength.

Motilium is generally considered safe, but there are certain contraindications that should be taken into consideration before using Motilium tablets.

• Motilium should not be used in patients with known QT prolongation or electrolyte disturbances such as hypokalemia and hypomagnesemia. It can increase the risk of serious cardiac arrhythmias and sudden death. Therefore, it is important to check a patient’s ECG prior to beginning treatment if they have any of these conditions.
• Motilium should not be taken by patients who have known hypersensitivity or intolerance to the drug due to its potential for severe allergic reactions including anaphylaxis.
• Women who are pregnant or breastfeeding should also avoid taking Motilium as it may cause harm to their unborn baby or infant child.
• Patients with hepatic impairment should also use caution when using Motilium as it has been associated with elevated liver enzymes in some cases.
• Individuals taking certain drugs that interact adversely with Motilium (such as dronedarone) should avoid using this medication due to an increased risk of side effects and serious health complications that could arise from combining the two medications together.

Motilium Tablet Dose for Nausea and vomiting:

• One tablet of 10mg three to four times daily.
• Some patients may require higher doses of up to 20mg ( 2 tablets 10mg) three or four times daily.

Motilium Tablet Dose for Gastroparesis:

• One tablet of 10mg three to four times daily.
• Some patients may require higher doses of up to 20mg ( 2 tablets 10mg) three or four times daily.

Motilium Tablet Dose for Reflux Esophagitis:

• one tablet of 10mg three or four times daily.

Motilium Tablet Dose for Breast milk production:

• One tablet of 10mg three times daily.

Motilium should be taken before meals because when taken after meals, its absorption is slightly delayed.

The maximum Dose is 40mg/day (4 Tablets)

Motilium is a dopamine antagonist drug because it works against dopamine-2 (D2) receptors in the brain and stomach. By blocking dopamine receptors in the upper gastrointestinal tract, Motilium increases the motility (contractions) of the stomach and small intestine. This helps to facilitate the movement of food from the stomach to the intestines, which can be especially beneficial in conditions like gastroparesis, where stomach emptying is delayed.

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