Gouric Tablet Uses

Gouric tablet is primarily used for the treatment and management of hyperuricemia in patients with gout. Hyperuricemia refers to elevated levels of uric acid in the blood, which can lead to the formation of uric acid crystals in the joints and other tissues. Following are some common uses of Gouric Tablet:

1. Gout: Gouric tablet is used for the treatment of gout, a type of arthritis caused by the buildup of uric acid crystals in the joints. It works by inhibiting the enzyme xanthine oxidase, which is involved in the production of uric acid. By reducing uric acid levels in the blood, Gouric helps prevent the formation of new crystals and promotes the dissolution of existing ones, thereby reducing inflammation and relieving symptoms of gout such as pain, swelling, and joint stiffness.

Off-label Uses of Gouric Tablet

1. Chronic Kidney Disease: In clinical experience, it is examined the use of Gouric tablet in patients with chronic kidney disease (CKD) to manage hyperuricemia and potentially slow the progression of kidney damage. Elevated uric acid levels are often associated with CKD, and reducing them may protect the kidneys.
2. Cardiovascular Disease: Gouric tablet may have cardiovascular benefits beyond gout management. It has been investigated for its potential to reduce inflammation, oxidative stress, and arterial stiffness, which are risk factors for cardiovascular disease.
3. Tumor Lysis Syndrome: Gouric tablet has been explored as a preventive treatment for tumor lysis syndrome, a potentially life-threatening condition that can occur as a result of cancer treatment. Tumor lysis syndrome involves the rapid release of intracellular contents into the bloodstream, including uric acid. Gouric tablets may help prevent or manage hyperuricemia during cancer treatment.

Gouric is one of the leading brands of Febuxostat, manufactured and marketed by Pharmevo (Pvt) Ltd, Pakistan.

The following are some alternative brands of Gouric and their manufacturers.

• Urigo : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Zurig : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Febux : Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.
• Uriguard : Atco Laboratories (Ltd) Pakistan.
• Febhil : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Hiloric : Highnoon Laboratories (Pvt) Ltd, Pakistan.
• Febuxin : AGP Pharma Pakistan.
• Baristat : Barrett Hodgson Pakistan (Pvt) Ltd.
• Febstat : Pharmatec Pakistan (Pvt) Ltd.
• Adenuric : Solace Pharma

Presently, Gouric is available in Tablets Form.

Gouric Tablets : 40mg and 80mg strengths.

There are some important contraindications that should be considered before using Gouric tablet.

Hypersensitivity: Gouric is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Gouric or any of its components. Allergic reactions can range from mild to severe and may include symptoms such as rash, itching, swelling, or difficulty breathing. If you have a known hypersensitivity, an alternative medication should be considered.

Severe Liver Disease: Gouric is contraindicated in patients with severe liver disease, as it may worsen liver function or cause further damage. This includes individuals with significant liver impairment or liver failure. Close monitoring of liver function is necessary in patients with pre-existing liver disease.

Concurrent Use with Azathioprine or Mercaptopurine: Gouric should not be used concomitantly with azathioprine or mercaptopurine, medications used to treat certain immune-related conditions or after organ transplantation. Concurrent use may increase the risk of bone marrow suppression, a condition that reduces the production of blood cells.

Pregnancy and Breastfeeding: Gouric is not recommended for use during pregnancy or while breastfeeding. Studies on the safety of Gouric in pregnant or breastfeeding individuals are limited, and its potential risks to the fetus or infant are not well-established. Alternative treatments should be considered in these situations.

The typical recommended dose of Gouric for gout management is as follows:

Gouric Tablet Initial Dose: The usual starting dose of Gouric for most patients is one tablet of 40mg once daily.

Gouric Tablet Maintenance Dose: After assessing the patient’s response and uric acid levels, the dose may be adjusted. The maintenance dose typically ranges from one tablet of 40mg or 80mg once daily, depending on the individual’s needs and the target uric acid levels.

Gouric is a medication that belongs to the class of drugs known as xanthine oxidase inhibitors. Its primary mode of action is the selective and reversible inhibition of the enzyme xanthine oxidase, which is involved in the metabolism of purines.

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