Diane 35 Tablet Uses

Diane 35 tablet is primarily used for gynecological issues specifically in the treatment of certain hormonal conditions. It is a synthetic form of estrogen that provides both contraceptive and anti-androgenic effects. Following are some common uses of Diane 35 Tablets:

1. Hormonal Contraception: Diane 35 tablet is used as an oral contraceptive, commonly known as a birth control pill. It helps to prevent pregnancy by inhibiting ovulation (the release of an egg from the ovary) and altering the cervical mucus, making it difficult for sperm to reach the uterus.
2. Polycystic Ovary Syndrome (PCOS): PCOS is a hormonal disorder characterized by irregular menstrual periods, excess androgen levels, and the formation of small cysts on the ovaries. Diane 35 tablets can be used to regulate menstrual cycles, reduce androgen levels, and alleviate some of the symptoms associated with PCOS.
3. Acne Treatment: Diane 35 tablet is also used to treat severe acne in women that is resistant to other treatments. It reduces the production of androgens (male hormones) and blocks their effects, which helps to decrease oil production and prevent clogged pores that contribute to acne.
4. Hirsutism: Hirsutism refers to the excessive growth of hair in women in areas typically associated with male hair patterns, such as the face, chest, or back. Diane 35 tablets can be used to manage hirsutism by blocking the effects of androgens, which play a role in stimulating hair growth.

Off-label Uses of Diane 35 Tablet

1. Premenstrual Syndrome (PMS) or Premenstrual Dysphoric Disorder (PMDD): Some healthcare providers may use Diane 35 tablets to manage the symptoms of PMS or PMDD, such as mood swings, irritability, bloating, and breast tenderness. The hormonal components in the medication may help regulate hormone levels and alleviate these symptoms.
2. Alopecia: Diane 35 tablet has been used off-label in the treatment of androgenetic alopecia, also known as male or female pattern baldness. The antiandrogenic properties of cyproterone acetate can help reduce the impact of androgens on hair follicles and potentially slow down hair loss.
3. Gender-Affirming Hormone Therapy: In transgender women (assigned male at birth), Diane 35 tablets may be used as part of a gender-affirming hormone therapy regimen. It can help suppress testosterone levels and promote feminizing effects such as breast development and reduction of body hair.
4. Hypersexuality or Paraphilias: In some cases, Diane 35 tablets may be used to help manage hypersexuality or paraphilic disorders by reducing sexual drive and behaviors.

Diane 35 is one of the leading brands with a combination of Ethinylestradiol + Cyproterone Acetate, manufactured and marketed by Bayer Schering Pharma.

The following are some alternative brands of Diane 35 and their manufacturers.

• Cyprodiol : Saffron Pharmaceuticals (Pvt) Ltd. Pakistan
• Acnot : Zafa Pharmaceutical Laboratories (Pvt) Ltd. Pakistan
• Fam 21 : Mass Pharma (Pvt) Ltd. Pakistan
• Eva 35 : Hansel Pharmaceuticals (Pvt) Ltd. Pakistan
• Femestelle 35 : Seatle Pharma Pakistan (Pvt) Ltd.
• Hytrade-C : Hygeia Pharmaceuticals. Pakistan

Presently, Diane 35 is available in Tablet form with the following strengths.

Diane 35 Tablet : Ethinylestradiol 35mcg + Cyproterone (Acetate) 2mg strengths.

Diane 35 has certain contraindications, which are situations or conditions where the use of the medication is not recommended due to the potential risks involved.

Pregnancy and breast-feeding: Diane 35 is contraindicated during pregnancy due to the potential risks to the developing fetus. It is also contraindicated in breastfeeding women as it may pass into breast milk and affect the nursing infant.

History of thromboembolic disorders: This medication is contraindicated in individuals with a history of venous thromboembolism (e.g., deep vein thrombosis, pulmonary embolism) or arterial thromboembolism (e.g., stroke, heart attack). Estrogens, such as ethinylestradiol, can increase the risk of blood clot formation, which can lead to these serious conditions.

History of or current liver disease: Diane 35 is contraindicated in individuals with severe liver disease or with a history of liver tumors. The medication can affect liver function, and individuals with impaired liver function may be at an increased risk of complications.

History of hormone-dependent cancers: The use of Diane 35 is contraindicated in individuals with a history of hormone-dependent cancers, such as breast or uterine cancer. Estrogens can promote the growth of these types of cancers, and therefore, caution is required.

Severe hypertriglyceridemia: Individuals with severe hypertriglyceridemia (high levels of triglycerides in the blood) are generally advised against using Diane 35, as it may further increase triglyceride levels and the risk of pancreatitis.

Hypersensitivity: Individuals with known hypersensitivity or allergy to ethinylestradiol, cyproterone acetate, or any other components of the medication should not use Diane 35.

Diane 35 Dose for Hormonal Contraception:

• One tablet is taken daily for 21 consecutive days.
• Followed by a 7-day hormone-free interval.
• The cycle is then repeated.

Diane 35 Done for Acne Treatment and Hirsutism:

• The initial dose may involve taking one tablet daily for several weeks.
• Followed by a maintenance dose that can be adjusted as necessary.

The mode of action of Diane 35 involves the individual actions of both components.

1. Ethinylestradiol (Estrogen Component):
   • Estrogen Receptor Binding: Ethinylestradiol binds to estrogen receptors in target tissues, exerting estrogenic effects. Estrogen receptors are present in various organs, including the ovaries, uterus, breasts, and hypothalamus.
   • Hormone Regulation: Ethinylestradiol regulates the menstrual cycle, promotes secondary sexual characteristics, and maintains the normal functioning of reproductive organs.
   • Inhibition of Follicle-Stimulating Hormone (FSH): Ethinylestradiol can suppress the release of FSH from the pituitary gland, leading to the inhibition of follicular development and ovulation.
2. Cyproterone Acetate (Antiandrogen Component):
   • Androgen Receptor Antagonism: Cyproterone acetate competes with androgens (male hormones) for binding to androgen receptors in target tissues.
   • Suppression of Androgen Activity: By blocking androgen receptors, cyproterone acetate inhibits the effects of androgens, such as testosterone and dihydrotestosterone (DHT).
   • Reduction of Sebaceous Gland Activity: Cyproterone acetate can reduce the activity of sebaceous glands in the skin, which helps in managing conditions like acne and hirsutism.

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Diane 35 Side Effeccts