Daflon Tablet Uses

Daflon tablet is an anti-edema agent, that is primarily used as a first-line treatment of edema and various circulatory disorders, particularly those related to venous insufficiency. The following are some common uses of Daflon Tablet:

1. Chronic Venous Insufficiency (CVI): Daflon tablet is commonly used for the treatment of CVI, which occurs when the valves in the leg veins do not function properly, leading to blood pooling, swelling, and discomfort. Daflon helps to improve venous tone, reduce venous inflammation, and increase the strength and integrity of the vein walls. It alleviates symptoms such as leg pain, heaviness, swelling, and cramps associated with CVI.
2. Venous Leg Ulcers: Daflon tablets may also be used as an adjunctive treatment for venous leg ulcers, which are chronic non-healing ulcers that develop due to CVI. By improving venous circulation and reducing inflammation, Daflon can help promote the healing of venous leg ulcers.
3. Hemorrhoids: Daflon tablet has been used in the management of hemorrhoids, which are swollen and inflamed blood vessels in the rectum or anus. It can help reduce the symptoms associated with hemorrhoids, such as pain, itching, swelling, and bleeding.

Off-label uses of Daflon Tablet

1. Lymphedema: Daflon tablets may be used off-label in the management of lymphedema, a condition characterized by the accumulation of lymph fluid, typically in the arms or legs. Daflon’s vagotonic and anti-inflammatory properties may help improve lymphatic flow and reduce swelling in lymphedema.
2. Varicose Veins: Daflon tablet can also be used in the treatment of varicose veins, which are enlarged and twisted veins usually found in the legs. It helps alleviate symptoms associated with varicose veins, such as pain, swelling, and heaviness.
3. Venous Thromboembolism (VTE) Prevention: Daflon tablet has a potential role in the prevention of venous thromboembolism, which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). It’s antithrombotic and vasoprotective properties that could help reduce the risk of VTE.

Daflon is one of the leading brands of Micronised Purified Flavonoid Fraction (MPFF), manufactured and marketed by Servier Research Pharmaceuticals Pakistan (Pvt) Ltd.

The following are some alternative brands of Daflon and their manufacturers.

• Dispedrol : Meezab International, Pakistan.

Presently, Daflon is available in Tablet Form.

Daflon Tablet : 500mg strength.

Daflon is generally considered safe for use, but there are a few contraindications or situations where caution should be exercised.

1. Hypersensitivity or allergy: Daflon should not be used in individuals who have a known hypersensitivity or allergy to any of its components. Allergic reactions can range from mild skin rash to severe anaphylaxis, which is a life-threatening allergic reaction. It’s important to check the ingredients and consult with a healthcare professional before using Daflon.
2. Pregnancy and breast-feeding: There is limited data available on the use of Daflon during pregnancy and breastfeeding. As a precautionary measure, Daflon is generally not recommended for use during pregnancy or breastfeeding due to the lack of sufficient safety data. It’s important to consult with a healthcare professional for alternative treatment options in these situations.
3. Children: The safety and efficacy of Daflon have not been established in children, and its use in this population is not recommended. The medication is primarily intended for use in adults.
4. Severe renal impairment: Daflon is primarily eliminated through the kidneys. In individuals with severe renal impairment (significant kidney dysfunction), caution should be exercised, and the use of Daflon may need to be adjusted or avoided. It’s important to consult with a healthcare professional to determine the appropriate dosage and use in individuals with impaired kidney function.

Daflon Dose for Mild to Moderate CVI:

• One Tablet of 500mg, twice a day.

Daflon Dose for Severe CVI:

• 1 to 2 Tablets of 500mg, twice daily.

The exact mode of action of Daflon is not fully understood, but it is believed to exert its therapeutic effects through several mechanisms:

1. Venotonic action: Daflon has been shown to increase the tone and contractility of the veins, helping to improve overall venous circulation. It works by enhancing the responsiveness of the venous smooth muscle to endogenous vasoconstrictors and reducing the distensibility of the veins.
2. Anti-inflammatory effects: Daflon has anti-inflammatory properties, which help reduce inflammation and damage in the venous walls. Chronic inflammation is a key component of CVI, and by reducing inflammation, Daflon helps improve venous function and decrease the symptoms associated with CVI.
3. Capillary protection: Daflon promotes the integrity and strength of the capillary walls, helping to prevent the leakage of fluid into the surrounding tissues. This property is particularly beneficial in CVI, where compromised venous circulation can lead to increased capillary permeability and edema.
4. Antioxidant activity: Daflon has been shown to have antioxidant effects, which help neutralize harmful free radicals and reduce oxidative stress in the veins. Oxidative stress can contribute to the progression of CVI, and Daflon’s antioxidant activity may help protect the venous walls from oxidative damage.