Clomid Tablet Uses

Clomid tablet belongs to a class of drugs called selective estrogen receptor modulators (SERMs). It is primarily used to induce ovulation in women who are having difficulty conceiving due to ovulatory disorders. Following are some common uses of Clomid Tablet:

1. Ovulation Induction: Clomid tablet is commonly used to stimulate ovulation in women who have irregular or absent menstrual cycles or who are not ovulating regularly. It helps to block the action of estrogen receptors in the hypothalamus, a part of the brain that regulates hormone production. By doing so, Clomid increases the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are responsible for follicle development and ovulation. This helps to promote the growth and release of mature eggs from the ovaries, increasing the chances of pregnancy.
2. Polycystic Ovary Syndrome (PCOS): Clomid tablet is also used for women with PCOS, a condition characterized by hormonal imbalances, irregular menstrual cycles, and often associated with infertility. It helps to induce ovulation and regulate the menstrual cycle in these individuals, increasing the likelihood of achieving pregnancy.
3. Unexplained Infertility: Clomid tablet may be used in couples with unexplained infertility, where no apparent cause for infertility has been identified after thorough evaluation. By promoting ovulation, it enhances the chances of pregnancy in such cases.

Off-label Uses of Clomid Tablet

1. Male Infertility: Although Clomid tablet is primarily used in women, it may be prescribed off-label for certain cases of male infertility. In men with low sperm count or abnormal sperm function, It can increase testosterone levels, stimulate sperm production, and improve sperm quality.
2. Luteal Phase Support: Clomid tablet may be used off-label to support the luteal phase of the menstrual cycle. The luteal phase is the post-ovulation phase when the lining of the uterus prepares for embryo implantation. By enhancing progesterone production and supporting the uterine lining, Clomid may be used as part of a luteal phase support protocol in IVF cycles.
3. Hormone Replacement Therapy (HRT): In some cases, Clomid may be used off-label in postmenopausal women as an alternative to traditional hormone replacement therapy. It may be considered for women who do not wish to use estrogen-based therapies due to personal preference or contraindications.

Clomid is one of the leading brands of Clomiphene Citrate, manufactured and marketed by Pacific Pharmaceuticals Ltd, Pakistan.

The following are some alternative brands of Clomid and their manufacturers.

• Ovi-F : Martin Dow Marker, Pakistan.
• Clomitab : Nabiqasim Industries (Pvt) Ltd, Pakistan.
• Prolifen : Chesi Pharmaceuticals (Pvt) Ltd, Pakistan.
• Cerophene : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Ferticol : Platinum Pharmaceuticals (Pvt) Ltd, Pakistan.
• Ovafen : OBS Pharma, Pakistan.
• Gynofen : Zafa Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.
• Namet : Saffron Pharmaceuticals (Pvt) Ltd, Pakistan.
• Clocit ; Cirin Pharmaceuticals (Pvt) Ltd, Pakistan.
• Femeg : Global Pharmaceuticals, Pakistan.
• Fertab : Shaigan Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Clomid is available in Tablet Form.

Clomid Tablet : 50mg strength.

Clomid has specific contraindications, which are conditions or situations where the use of Clomid is not recommended due to potential risks or adverse effects.

• Hypersensitivity or allergy: Clomid is contraindicated in individuals who have a known hypersensitivity or allergy to Clomid or any of its components. Allergic reactions can range from mild skin rash to severe anaphylaxis, which is a life-threatening allergic reaction.
• Ovarian cysts: Clomid should not be used if there are existing or suspected ovarian cysts (enlarged fluid-filled sacs on the ovaries). The use of Clomid in the presence of ovarian cysts may lead to further enlargement of the cysts and increase the risk of complications such as ovarian torsion (twisting) or rupture.
• Abnormal vaginal bleeding: Clomid is contraindicated in women with abnormal vaginal bleeding of unknown origin. It is important to determine the cause of the abnormal bleeding before initiating treatment, as Clomid may exacerbate certain underlying conditions.
• Pregnancy: Clomid should not be used during pregnancy. It is specifically intended to stimulate ovulation and should not be initiated or continued if pregnancy is confirmed. If pregnancy occurs while taking Clomid, it should be discontinued and appropriate measures are taken.
• Liver disease: Clomid is primarily metabolized in the liver, and individuals with severe liver disease may have impaired drug metabolism and clearance. Clomid should be used with caution in patients with significant liver impairment or avoided altogether.
• Pituitary tumor: Clomid is contraindicated in individuals with known or suspected pituitary tumors. Clomid may stimulate the growth of these tumors and potentially lead to complications.

Clomid Dose for Ovulation Induction in Women:

• One table of 50mg per day for five days, usually starting on the 5th day of the menstrual cycle.
• If ovulation does not occur with the initial dose, the dosage may be increased in subsequent cycles, up to a maximum of 150mg (Three Tablets of Clomid) per day.
• The duration of treatment can vary, but it is usually limited to three to six cycles. If pregnancy does not occur after this period, further evaluation may be necessary.

Clomid Dose for Polycystic Ovary Syndrome (PCOS):

• One Tablet of 50mg per day, similar to ovulation induction. However, the dose may be increased if ovulation does not occur or if it is not successful.

Clomid Dose for Unexplained Infertility:

• One Tablet of 50mg per day. The duration of treatment and potential dosage adjustments will be determined by the healthcare professional based on the response to treatment and individual circumstances.

Clomid is a selective estrogen receptor modulator (SERM) with a complex mode of action that primarily acts on the hypothalamus and pituitary gland.

1. Estrogen receptor blockade: Clomid competitively binds to estrogen receptors in the hypothalamus. By occupying these receptors, it prevents the inhibitory effects of endogenous estrogens (such as estradiol) on the secretion of gonadotropin-releasing hormone (GnRH).
2. Increased GnRH secretion: With the blockade of estrogen receptors, the secretion of GnRH from the hypothalamus is increased. GnRH is a hormone that stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland.
3. Enhanced FSH and LH secretion: The increased GnRH secretion leads to an increase in FSH and LH secretion from the pituitary gland. FSH is responsible for the development of ovarian follicles, while LH triggers ovulation.
4. Follicular development: The elevated levels of FSH promote the growth and development of ovarian follicles. Multiple follicles may mature in response to Clomid treatment.