Actifed-P Cold Tablet Uses

Actifed-P Cold tablet is used to relieve pain, fever, and symptoms associated with respiratory conditions, such as the common cold or allergies. It is a compound medication that provides analgesic, decongestant, and antihistamine effects. Following are some common and off-label uses of Actifed-P Cold tablets:

Common Uses of Actifed-P Cold Tablet

1. Common Cold: Actifed-P Cold tablet is often used to relieve symptoms of the common cold, including nasal congestion, runny nose, headache, mild pain, and fever.
2. Allergic Rhinitis: Actifed-P Cold tablet can be used for the relief of symptoms associated with allergic rhinitis, such as sneezing, nasal congestion, and itchy eyes.
3. Sinus Congestion: The decongestant properties of Actifed-P Cold tablet make it helpful in alleviating sinus congestion.

Off-label Uses of Actifed-P Cold Tablet

1. Sinusitis: Actifed-P Cold tablet may be considered off-label for relieving nasal congestion associated with sinusitis.
2. Influenza (Flu-like Symptoms): In some cases, Actifed-P Cold tablet might be used off-label to alleviate symptoms associated with influenza, such as fever, nasal congestion, and mild pain.
3. Hay Fever (Allergic Rhinitis): While the Actifed-P Cold tablet is used to address allergy symptoms, its use may extend to off-label relief of hay fever symptoms. Its antihistamine effects can help with allergy symptoms, including sneezing and itchy eyes.
4. Upper Respiratory Infections: Off-label use might include the treatment of upper respiratory tract infections that present with symptoms such as fever, nasal congestion, and headache.

Actifed-P Cold is one of the leading brands of (Paracetamol+Pseudoephedrine+Triprolidine), manufactured and marketed by GlaxoSmithKline.

Below are some available similar brands that can be used as an alternative to Actifed-P Cold tablet.

• Acfin-P : Swiss Pharmaceuticals (Pvt) Ltd.
• Dcold : Multinational Business Link.
• Dosafed-P : Dosaco Laboratories.
• Flucol : Berrett Hodgson Pakistan (Pvt) Ltd.
• Flu-P : Semos Pharmaceuticals (Pvt) Ltd.
• Flutab : Phar-Man Laboratories.
• Komkold : Adanjee Pharmaceuticals (Pvt) Ltd.
• Neophed-P : Hamza Pharmaceuticals (Pvt) Ltd.
• Prolifed-P : Derma Techno Pakistan.

Presently, Actifed-P Cold is available in Tablet and Syrup Forms with the following strengths.

Actifed-P Cold Tablet:

• Paracetamol 300mg
• Pseudoephedrine 36mg
• Triprolidine 1.5mg

Actifed-P Cold Syrup:

• Paracetamol 80mg/5ml
• Pseudoephedrine 30mg/5ml
• Triprolidine 1.25mg/5ml

Paracetamol should not be taken if you have liver disease or kidney disease since it may worsen these conditions or increase your risk for side effects such as liver toxicity or kidney failure. People who are allergic to paracetamol should not take this medication as it may cause anaphylaxis (severe allergic reaction). Additionally, certain medications may interfere with how paracetamol works in your body so check with your doctor before taking this medication while taking other medications.

Pseudoephedrine should not be consumed if you have hypertension (high blood pressure); glaucoma; diabetes mellitus; enlarged prostate gland /urinary retention problems; heart disease /arrhythmia /coronary artery disease; hyperthyroidism; pregnant women since pseudoephedrine can cross placenta barrier causing harm to the fetus, breastfeeding mothers since pseudoephedrine passes into breast milk causing harm infants & amp; young children under 6 years old due its tendency produce serious side effects even with smaller amounts ingested than adults would tolerate without serious adverse reactions occurring e.g. excitability agitation insomnia restlessness irritability aggression seizures tremor palpitations tachycardia hypertension arrhythmias myocardial infarction stroke cerebral hemorrhage cardiac arrest death, etc.

Triprolidine should not be used in people who are sensitive to it or any of its components; those with narrow-angle glaucoma; those taking monoamine oxidase inhibitors (MAOIs); those with urinary retention; and pregnant women unless prescribed by their doctor. People should also inform their healthcare provider if they have any other medical conditions before taking this medication such as high blood pressure, heart disease, diabetes, glaucoma, or kidney disease.

Actifed-P Cold Tablets Dose for Adults (12 Years and Over):

• 1 tablet every 4 hours do not take more than 6 tablets in 24 hours.

Actifed-P Cold Syrup Dose for Children (6-12 Years Old):

• 1 teaspoon of 5ml after 4-6 hours, do not take more than 20ml in 24 hours.

Actifed-P Cold works on specific receptors in the body that are responsible for allergies, pain, and congestion.

Paracetamol: Once absorbed into systemic circulation it binds mainly to albumin proteins before entering tissues where it exerts its pharmacological action through inhibition of prostaglandin synthesis via inhibition of cyclooxygenase enzymes COX1.

Pseudoephedrine: Works primarily through stimulation α -adrenergic receptors located on Blood Vessel walls leading to vasoconstriction narrowing these vessels reducing the amount of fluid accumulation. Additionally, stimulation β -of adrenergic receptors located in bronchiolar smooth muscle cell’s airways leads to bronchodilation increasing airflow and reducing obstruction allowing easier breathing.

Triprolidine: The mode of action for triprolidine involves inhibiting histamine receptors (H1) on cells throughout the body which prevents them from binding with histamine molecules that are produced by certain cells during an allergic reaction.

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Actifed-P Cold Side Effects