Brexin Side Effects - Piroxicam Beta-Cyclodextrin Side Effects

What Are The Possible Side Effects of Brexin?

The most commonly found side effects are gastrointestinal disturbances which are represented by nausea, epigastric distress, constipation and diarrhoea. Other noted side effects: signs of hypersensitivity (skin rash), headache, vertigo, asthenia, changes in blood chemistry, increase of BUN. Rare side effects: gastric ulcers with or without hemorrhages, vomiting, allergic oedema of the face and hands, increase of cutaneous photosensitivity, ocular disturbances, aplastic anemia, pancytopenia, thrombocytopenia, increase of liver function parameters, jaundice, acute renal insufficiency, water retention that may occur in the form of oedema (mainly ankle oedema), or cardiocirculatory disturbances (hypertension, congestive heart failure). Sporadic cases of gastric ulcer with perforation, Stevens-Johnson syndrome, Lyell's disease, agranulocytosis, bladder disorders, shock and warning symptoms, acute heart failure, stomatitis, alopecia and nail growth disorders have been associated with the use of piroxicam.

Contraindications

Brexin Tablets must not be used in subjects known to be hypersensitive to the drug, nor in subjects with gastroduodenal ulcer, gastritis, dyspepsia, severe hepatic or renal disturbances, severe heart failure, severe hypertension, severe blood alterations or hemorrhagic diathesis. It is possible that cross sensitivity with acetylsalicylic acid or other NSAIDs exist. Therefore, piroxicam must not be administered to patients in whom acetylsalicylic acid or other NSAIDs induce the symptoms of asthma, rhinitis or urticaria. The product is contraindicated in ascertained or suspected pregnancy, during lactation and in children.

In the event of an overdosage with Brexin a supportive and symptomatic therapy should be given.

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